Comparative Effectiveness of Smoking Cessation Medications to Attenuate Weight Gain Following Cessation

被引:6
作者
Yang, Mo [1 ]
Chen, Hua [1 ]
Johnson, Michael L. [1 ]
Essien, Ekere James [1 ]
Peters, Ronald J., Jr. [2 ]
Wang, Xin [1 ]
Abughosh, Susan [1 ]
机构
[1] Univ Houston, Dept Pharmaceut Hlth Outcomes & Policy, Houston, TX 77030 USA
[2] Univ Texas Hlth Sci Ctr Houston, Ctr Hlth Promot & Prevent Res, Houston, TX 77030 USA
关键词
Comparative effectiveness; smoking cessation; obesity; weight change; varenicline; bupropion; SUSTAINED-RELEASE BUPROPION; RECEPTOR PARTIAL AGONIST; BODY-WEIGHT; CONTROLLED-TRIAL; BLOOD-PRESSURE; RISK-FACTOR; PLACEBO; VARENICLINE; SMOKERS; INTERVENTION;
D O I
10.3109/10826084.2015.1126744
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Objective: To compare the postcessation weight gain following the use of different FDA-approved smoking cessation medications among obese smokers. Methods: A retrospective cohort study was conducted using the General Electric (GE) electronic medical record database (2006-2011). The cohort consisted of obese adult smokers newly initiating use of an FDA-approved smoking cessation medication (i.e., bupropion vs. varenicline). The outcome variable was weight change at 3, 6, or 12months following the first prescription. Descriptive analyses and t-tests were conducted to assess the frequency distribution of sample characteristics and their association with the postcessation weight change. Multivariate linear regression models were carried out to compare the weight change among the FDA-approved smoking cessation medications and to identify predictors of weight change at 3, 6, and 12months after assessing the model assumptions. Results: The mean weight gain was 1.14 pounds (+/- 17.26), 2.06 pounds (+/- 18.46), and 3.06 pounds (+/- 20.78) at 3-, 6-, and 12-month, respectively. Obese smokers who were prescribed varenicline had a mean weight gain of 1.18 pounds (+/- 16.75), 2.14 pounds (+/- 18.14), and 3.12 pounds (+/- 20.89) for each follow up, while those who were prescribed bupropion had a mean weight gain of 0.23 pounds (+/- 25.90), 0.22 pounds (+/- 25.32), and 1.47 pounds (+/- 17.50), respectively. Descriptive analysis showed that obese smokers taking bupropion had less weight gain than those taking varenicline at each follow up; however, this association was not statistically significant after accounting for all covariates. Conclusions: While patients using bupropion gained slightly less weight compared to those using varenicline, type of smoking cessation medication was not a significant predictor of weight change in the multivariate linear regression model.
引用
收藏
页码:586 / 597
页数:12
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