Chromothripsis in cancer cells: An update

被引：91

作者：

Rode, Agata ^{[1
]}

Maass, Kendra Korinna ^{[1
]}

Willmund, Karolin Viktoria ^{[1
]}

Lichter, Peter ^{[1
]}

Ernst, Aurelie ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Mol Genet, Neuenheimer Feld 580, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF CANCER | 2016年 / 138卷 / 10期

关键词：

chromothripsis; genome instability; catastrophic genomic rearrangement; PREMATURE CHROMOSOME CONDENSATION; BREAKPOINT CLUSTER REGION; DOUBLE-STRAND BREAKS; DNA-DAMAGE; GENOMIC REARRANGEMENT; UTERINE LEIOMYOMAS; EVOLUTION; MECHANISMS; RADIATION; ARCHITECTURE;

D O I：

10.1002/ijc.29888

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous formation of multiple double-strand breaks, which are repaired by error-prone mechanisms. Since then, the occurrence of chromothripsis was detected in a wide range of tumor entities. In this review, we will discuss potential mechanisms of chromothripsis initiation in cancer and outline the prevalence of chromothripsis across entities. Furthermore, we will examine how chromothriptic events may promote cancer development and how they may affect cancer therapy.

引用

页码：2322 / 2333

页数：12

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