STING signaling in tumorigenesis and cancer therapy: A friend or foe?

被引：54

作者：

He, Liangmei ^{[1
]}

Xiao, Xiaomei ^{[1
]}

Yang, Xi ^{[2
]}

Zhang, Zixiang ^{[1
]}

Wu, Longhuo ^{[3
]}

Liu, Zhiping ^{[2
]}

机构：

[1] Gannan Med Univ, Affiliated Hosp 1, Ganzhou 341000, Jiangxi, Peoples R China

[2] Gannan Med Univ, Sch Basic Med, Ganzhou 341000, Jiangxi, Peoples R China

[3] Gannan Med Univ, Coll Pharm, Ganzhou 341000, Jiangxi, Peoples R China

来源：

CANCER LETTERS | 2017年 / 402卷

关键词：

STING; Tumorigenesis; Cancer therapy; Metastasis; C-DI-GMP; CYTOSOLIC DNA SENSOR; I INTERFERON; CYCLIC DINUCLEOTIDE; SUPPRESSOR-CELLS; T-CELLS; AUTOIMMUNE-DISEASE; TUMOR-REGRESSION; EPITHELIAL-CELLS; PROSTATE-CANCER;

D O I：

10.1016/j.canlet.2017.05.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stimulator of interferon genes (STING) is a DNA sensor and an important cytoplasmic adaptor for other DNA sensors, such as Z-DNA binding protein 1 (DAI), DEAD-box helicase 41 (DDX41), and interferon-gamma-inducible protein 16 (IF116). The activation of STING signaling leads to the production of type I interferons and some other pro-inflammatory cytokines, which are critical for host defense against viral infection. Recent accumulating evidences suggest that STING is also involved in tumor development. However, the role of STING signaling in tumorigenesis is complicated, and a comprehensive review is still lacking. In this paper, we provided an overview of the dual role of STING signaling in tumor development from clinical significance to fundamental mechanisms, as well as its pre-clinical application in cancer therapy. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：203 / 212

页数：10

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