The psychosis threshold in Ultra High Risk (prodromal) research: Is it valid?

被引：115

作者：

Yung, Alison R. ^{[1
]}

Nelson, Barnaby ^{[1
]}

Thompson, Andrew ^{[1
]}

Wood, Stephen J. ^{[2
]}

机构：

[1] Univ Melbourne, Orygen Youth Hlth Res Ctr, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Melbourne Neuropsychiat Ctr, Parkville, Vic 3052, Australia

来源：

SCHIZOPHRENIA RESEARCH | 2010年 / 120卷 / 1-3期

关键词：

Schizophrenia; Prodrome; Psychotic disorder; High risk; Clinical high risk; Risk syndrome; DSMV; RANDOMIZED CONTROLLED-TRIAL; CLINICAL-SAMPLE; FOLLOW-UP; INTERRATER RELIABILITY; SCHIZOPHRENIA PRODROME; COGNITIVE THERAPY; YOUNG-PEOPLE; PREDICTION; EXPERIENCES; PHASE;

D O I：

10.1016/j.schres.2010.03.014

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

"Transition to psychosis" has been the outcome of interest in Ultra High Risk (UHR) and "prodromal" studies. However, the point at which an individual crosses the line from high risk or prodromal state to psychosis threshold is arbitrary. There have been few attempts to examine whether this threshold has any validity in terms of biological markers or course and outcome. More research is needed to determine if the current point at which a person is declared "psychotic" is valid. Indeed some persons labeled as having developed psychosis may quickly recover. In such a situation their transition could be seen as "trivial". Others who do not make "transition" may have worse outcomes. Validation of the transition point is an important issue as "risk syndrome for psychosis" (psychosis prodrome) is being considered for inclusion in the DSMV. Further, much research attempts to distinguish markers for psychotic disorders by examining the differences between UHR individuals who do and do not develop psychosis. Thus it behooves us not just to have this risk syndrome validated, but to have the hypothetical endpoint of psychosis validated as well. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 42 条

[1]

Amminger G, 2007, SCHIZOPHRENIA BULL, V33, P418

[2] Cognitive-behavioral therapy in the pre-psychotic phase:: An exploratory study [J].

Bechdolf, A ;

Veith, V ;

Schwarzer, D ;

Schormann, M ;

Stamm, E ;

Janssen, B ;

Berning, J ;

Wagner, M ;

Klosterkötter, J .

PSYCHIATRY RESEARCH, 2005, 136 (2-3) :251-255

[3]

BEISER M, 1993, AM J PSYCHIAT, V150, P1349

[4] Outreach and support in south London (OASIS): implementation of a clinical service for prodromal psychosis and the at risk mental state [J].

Broome, MR ;

Woolley, JB ;

Johns, LC ;

Valmaggia, LR ;

Tabraham, P ;

Gafoor, R ;

Bramon, E ;

McGuire, PK .

EUROPEAN PSYCHIATRY, 2005, 20 (5-6) :372-378

[5] Prediction of psychosis in youth at high clinical risk [J].

Cannon, Tyrone D. ;

Cadenhead, Kristin ;

Cornblatt, Barbara ;

Woods, Scott W. ;

Addington, Jean ;

Walker, Elaine ;

Seidman, Larry J. ;

Perkins, Diana ;

Tsuang, Ming ;

McGlashan, Thomas ;

Heinssen, Robert .

ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (01) :28-37

[6] Anticipating DSM-V: Should Psychosis Risk Become a Diagnostic Class? [J].

Carpenter, William T. .

SCHIZOPHRENIA BULLETIN, 2009, 35 (05) :841-843

[7] SCHIZOPHRENIAS AS NERVOUS TYPES [J].

CLARIDGE, G .

BRITISH JOURNAL OF PSYCHIATRY, 1972, 121 (560) :1-&

[8] The schizophrenia prodrome: treatment and high-risk perspectives [J].

Cornblatt, B ;

Lencz, T ;

Obuchowski, M .

SCHIZOPHRENIA RESEARCH, 2002, 54 (1-2) :177-186

[9] The schizophrenia prodrome revisited: A neurodevelopmental perspective [J].

Cornblatt, BA ;

Lencz, T ;

Smith, CW ;

Correll, CU ;

Auther, AM ;

Nakayama, E .

SCHIZOPHRENIA BULLETIN, 2003, 29 (04) :633-651

[10] Schizophrenia and depression:: Challenging the paradigm of two separate diseases -: A controlled study of schizophrenia, depression and healthy controls [J].

Häfner, H ;

Maurer, K ;

Trendler, G ;

an der Heiden, W ;

Schmidt, M ;

Könnecke, R .

SCHIZOPHRENIA RESEARCH, 2005, 77 (01) :11-24

← 1 2 3 4 5 →