A Bulky Three-Hindered Quadrant Bisphosphine Ligand: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes

被引：21
作者：
Sawatsugawa, Yuuki [1 ]
Tamura, Ken [1 ]
Sano, Natsuhiro [1 ]
Imamoto, Tsuneo [1 ,2 ]
机构：
[1] Nippon Chem Ind Co Ltd, Organ R&D Dept, Koto Ku, Tokyo 1368515, Japan
[2] Chiba Univ, Grad Sch Sci, Dept Chem, Inage Ku, Chiba 2638522, Japan
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 22期
关键词：
HIGHLY ENANTIOSELECTIVE HYDROGENATION; CHIRAL PHOSPHINE-LIGANDS; TETRASUBSTITUTED ENAMIDES; ACID-DERIVATIVES; AMINO-ACIDS; SMS-PHOS; DIPHOSPHINES; BORANES; OLEFINS; SCOPE;
D O I：
10.1021/acs.orglett.9b02702
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A bulky three-hindered quadrant bisphosphine ligand, di-1-adamantylphosphino(tert-butylmethylphosphino)methane, named BulkyP*, has been synthesized via a convergent short pathway with chromatography-free procedures. The ligand is a crystalline solid and can be readily handled in air. Its rhodium(I) complex exhibits very high enantioselectivities and catalytic activities in the asymmetric hydrogenation of functionalized alkenes.
引用
收藏
页码：8874 / 8878
页数：5
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