Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative

被引:24
作者
Gersing, Alexandra S. [1 ]
Schwaiger, Benedikt J. [1 ]
Heilmeier, Ursula [1 ]
Joseph, Gabby B. [1 ]
Facchetti, Luca [1 ]
Kretzschmar, Martin [1 ]
Lynch, John A. [2 ]
McCulloch, Charles E. [2 ]
Nevitt, Michael C. [2 ]
Steinbach, Lynne S. [1 ]
Link, Thomas M. [1 ]
机构
[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, 185 Berry St,Suite 350, San Francisco, CA 94107 USA
[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, 550 16th St,2nd Floor, San Francisco, CA 94158 USA
基金
美国国家卫生研究院;
关键词
Chondrocalcinosis; Osteoarthritis; Magnetic resonance imaging; Musculoskeletal imaging; Cartilage imaging; CALCIUM PYROPHOSPHATE DIHYDRATE; CARTILAGE T2 MEASUREMENTS; ARTICULAR-CARTILAGE; PHYSICAL-ACTIVITY; MORPHOLOGIC ABNORMALITIES; CRYSTAL DEPOSITION; SPACE WIDTH; CALCIFICATION; LESIONS; REPRODUCIBILITY;
D O I
10.1007/s00330-016-4608-8
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To evaluate the ability of different MRI sequences to detect chondrocalcinosis within knee cartilage and menisci, and to analyze the association with joint degeneration. Subjects with radiographic knee chondrocalcinosis (n = 90, age 67.7 +/- 7.3 years, 50 women) were selected from the Osteoarthritis Initiative and matched to controls without radiographic chondrocalcinosis (n = 90). Visualization of calcium-containing crystals (CaC) was compared between 3D T1-weighted gradient-echo (T1GE), 3D dual echo steady-state (DESS), 2D intermediate-weighted (IW), and proton density (PD)-weighted fast spin-echo (FSE) sequences obtained with 3T MRI and correlated with a semiquantitative CaC score obtained from radiographs. Structural abnormalities were assessed using Whole-Organ MRI Score (WORMS) and logistic regression models were used to compare cartilage compartments with and without CaC. Correlations between CaC counts of MRI sequences and degree of radiographic calcifications were highest for GE (r(T1GE) = 0.73, P < 0.001; r(DESS) = 0.68, P < 0.001) compared to other sequences (P > 0.05). Meniscus WORMS was significantly higher in subjects with chondrocalcinosis compared to controls (P = 0.005). Cartilage defects were significantly more frequent in compartments with CaC than without (patella: P = 0.006; lateral tibia: P < 0.001; lateral femur condyle: P = 0.017). Gradient-echo sequences were most useful for the detection of chondrocalcinosis and presence of CaC was associated with higher prevalence of cartilage and meniscal damage. aEuro cent Magnetic resonance imaging is useful for assessing burden of calcium-containing crystals (CaC). aEuro cent Gradient-echo sequences are superior to fast spin echo sequences for CaC imaging. aEuro cent Presence of CaC is associated with meniscus and cartilage degradation.
引用
收藏
页码:2497 / 2506
页数:10
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