Palladium-Catalyzed Ortho-Arylation of Carbamate-Protected Estrogens

被引：11
作者：
Bedford, Robin B. [1 ]
Brenner, Peter B. [1 ]
Durrant, Steven J. [2 ]
Gallagher, Timothy [1 ]
Mendez-Galvez, Carolina [1 ]
Montgomery, Michelle [1 ]
机构：
[1] Univ Bristol, Sch Chem, Cantocks Close, Bristol BS8 1TS, Avon, England
[2] Vertex Pharmaceut Ltd Europe, 86-88 Jubilee Ave, Abingdon OX14 4RW, Oxon, England
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 09期
基金：
英国工程与自然科学研究理事会;
关键词：
BOND FORMATION; RECEPTOR;
D O I：
10.1021/acs.joc.6b00532
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The palladium-catalyzed ortho-arylation of diethyl carbamate-protected estrone and estriol with aryl iodides gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol, or estriol depending on the method used.
引用
收藏
页码：3473 / 3478
页数：7
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