It is generally assumed that the Jovian planets share common features as a consequence of similar formation and evolutionary processes. Nevertheless, Uranus is the only one without observed outer satellites and with a large spin axis inclination. This obliquity is usually attributed to a great tangential collision with another protoplanet during the stage of planetary formation. If the Great Collision took place, it imparted enough orbital impulse to unbind the orbits of preexisting outer satellites. In this work we settle dynamical constraints to Uranus' Great Collision in connection with the observational evidence.