Management of Eosinophilic Esophagitis Based on Pathophysiological Evidence

被引：5

作者：

van Rhijn, Bram D. ^{[1
]}

Bredenoord, Albert J. ^{[2
]}

机构：

[1] Univ Med Ctr, Dept Dermatol & Allergol, Huispostnummer L 00-509,POB 85500, NL-3508 GA Utrecht, Netherlands

[2] Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2017年 / 51卷 / 08期

关键词：

eosinophilic esophagitis; epithelial barrier; etiology; PPI-REE; treatment; GASTROESOPHAGEAL-REFLUX DISEASE; THYMIC STROMAL LYMPHOPOIETIN; TOPICAL STEROID-THERAPY; ENDOSCOPIC REFERENCE SCORE; CRTH2 ANTAGONIST OC000459; HIGH-RESOLUTION MANOMETRY; 6-FOOD ELIMINATION DIET; MUCOSAL INTEGRITY; ADULT PATIENTS; SWALLOWED FLUTICASONE;

D O I：

10.1097/MCG.0000000000000879

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Over the past decades eosinophilic esophagitis (EoE) has been increasingly diagnosed, and significant progress has been made in our understanding of its pathophysiology. As EoE cannot be cured yet, treatment goals are suppression of disease activity and symptoms as well as the prevention of progression to a more severe disease phenotype. Disease-modifying treatment options can be divided into dietary therapy and immunosuppressive medications, of which topical steroids have been most investigated, yet are still prescribed off-label. In this review, we will summarize recent advances in our understanding of EoE and discuss the mechanisms of action of current treatment options, with emphasis on the role of the esophageal epithelial barrier and the effects of proton-pump inhibitors in the management of patients with EoE.

引用

页码：659 / 668

页数：10

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