SRC-3, a Steroid Receptor Coactivator: Implication in Cancer

被引：26
作者：
Li, Licen [1 ,2 ]
Deng, Chu-Xia [1 ,2 ]
Chen, Qiang [1 ,2 ]
机构：
[1] Univ Macau, Fac Hlth Sci, Canc Ctr, Macau, Peoples R China
[2] Univ Macau, Fac Hlth Sci, Ctr Precis Med Res & Training, Macau, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 09期
基金：
中国国家自然科学基金;
关键词：
SRC-3; AIB1; coactivator; cancer; HEPATOCELLULAR-CARCINOMA PROGRESSION; INDEPENDENT PROGNOSTIC MARKER; VIRUS X PROTEIN; BREAST-CANCER; CELL-PROLIFERATION; TRANSCRIPTIONAL COACTIVATOR; TAMOXIFEN RESISTANCE; ESTROGEN-RECEPTOR; OVARIAN-CANCER; LUNG-CANCER;
D O I：
10.3390/ijms22094760
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.
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页数：22
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