Energy-dependent UV light-induced disruption of (-) sulpiride antagonism of dopamine

被引：18

作者：

Raffa, RB

Valdez, JM

Holland, LJ

Schulingkamp, RJ

机构：

[1] Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19140 USA

[2] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA

[3] Temple Univ, TMARC Program, Philadelphia, PA 19140 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 406卷 / 03期

关键词：

D2; receptor; UV light; planaria;

D O I：

10.1016/S0014-2999(00)00730-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The dopamine D2 receptor antagonist sulpiride decreases the spontaneous locomotor activity of Planaria in an enantiomeric-selective and dose-dependent manner. We now report that (-)sulpiride (0.1 muM)-induced decrease of planarian locomotor activity is significantly (P < 0.05) attenuated by low-energy (366 nm) ultraviolet (UV) light and to a greater extent by high-energy (254 nm) UV light. The phenomenon offers a novel approach for studying dopamine D2 receptor transduction processes in a simple in vivo model. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：R11 / R12

页数：2

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