Determination of Zilpaterol in Livestock Products by LC-MS/MS

被引:0
作者
Asakura, Takayuki [1 ]
Kitamura, Mariko [1 ]
Ishikawa, Takaaki [1 ]
Iida, Tomonari [1 ]
Nakazato, Mitsuo [1 ]
Yasuda, Kazuo [1 ]
Nemoto, Satoru [2 ]
机构
[1] Inc Fdn Tokyo Kenbikyo In, Inst Food & Environm Sci, Chuo Ku, 5-1 Toyomi Cho, Tokyo 1040055, Japan
[2] Natl Inst Hlth Sci, Kawasaki Ku, 3-25-26 Tonomachi, Kawasaki, Kanagawa 2109501, Japan
来源
FOOD HYGIENE AND SAFETY SCIENCE | 2019年 / 60卷 / 05期
关键词
zilpaterol; beta(2)-agonist; livestock; LC-MS/MS; MASS; URINE; ASSAY;
D O I
暂无
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
An analytical method for the determination of zilpaterol in livestock products was developed. The sample was stirred with n-hexane and n-hexane saturated acetonitrile, and zilpaterol in the sample was extracted with acetonitrile. The extract was cleaned up on a ODS cartridge column (1 g) and SCX cartridge column (500 mg). The LC separation was carried out using an Inertsil ODS-4 column and linear gradient elution with 0.1%formic acid and acetonitrile containing 0.1% formic acid as mobile phase. Detection of MS was carried out positive ion electrospray ionization mode. Average recoveries (n = 5) of zilpaterol from 6 kinds of livestock products fortified at the MRLs (0.01 mg/kg) were 87.0-99.4%, and the relative standard deviations were 2.4-6.3%. The limits of quantitation were 0.01 mg/kg.
引用
收藏
页码:127 / 133
页数:7
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