Relationship between serum ferritin and inflammatory biomarkers with insulin resistance in a Persian population with type 2 diabetes and healthy people

被引：28
作者：
Ashourpour, Mahkameh [1 ]
Djalali, Mahmoud [1 ]
Djazayery, Abolghassem [1 ]
Eshraghian, Mohammad Reza [2 ]
Taghdir, Maryam [1 ]
Saedisomeolia, Ahmad [1 ]
机构：
[1] Univ Tehran Med Sci, Dept Biochem & Nutr, Sch Publ Hlth, Tehran, Iran
[2] Univ Tehran Med Sci, Dept Epidemiol & Biostat, Sch Publ Hlth, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2010年 / 61卷 / 03期
关键词：
Inflammation; insulin resistance; serum ferritin; type; 2; diabetes; IRON-METABOLISM; MELLITUS; ASSOCIATION; TRANSFERRIN; HEMOGLOBIN; IMPACT; ADULTS; WOMEN; DYSFUNCTION; ONSET;
D O I：
10.3109/09637480903555150
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Background The correlation between body iron stores and inflammation with insulin resistance in type 2 diabetes is not thoroughly investigated, especially in the Persian population. Methods A cross-sectional study was designed in Tehran, Iran. Fifty-four people with type 2 diabetes and 53 matched healthy participants were included. Serum ferritin, total iron binding capacity, insulin resistance, C-reactive protein and tumor necrosis factor-alpha were measured in both groups. Results Diabetic patients had higher insulin resistance, hemoglobin A(1)C and serum ferritin. Significant positive correlations were observed between insulin resistance with serum ferritin and tumor necrosis factor-alpha and between serum ferritin and tumor necrosis factor-alpha in diabetic patients. Conclusions Inter-relationship between insulin resistance, serum ferritin and TNF-alpha was found in type 2 diabetic patients. Serum iron even in the normal range had positive correlation with insulin resistance. It may be because the normal ranges determined for serum ferritin are too wide and the criteria for iron overload are too high.
引用
收藏
页码：316 / 323
页数：8
相关论文
共 31 条
[1]   Inflammation, insulin resistance, and diabetes-mendelian randomization using CRP haplotypes points upstream [J].
Brunner, Eric J. ;
Kivimaeki, Mika ;
Witte, Daniel R. ;
Lawlor, Debbie A. ;
Smith, George Davey ;
Cooper, Jackie A. ;
Miller, Michelle ;
Lowe, Gordon D. O. ;
Rumley, Ann ;
Casas, Juan P. ;
Shah, Tina ;
Humphries, Steve E. ;
Hingorani, Aroon D. ;
Marmot, Michael G. ;
Timpson, Nicholas J. ;
Kumari, Meena .
PLOS MEDICINE, 2008, 5 (08) :1278-1286
[2]   INSULIN IS A PROMINENT MODULATOR OF THE CYTOKINE-STIMULATED EXPRESSION OF ACUTE-PHASE PLASMA-PROTEIN GENES [J].
CAMPOS, SP ;
BAUMANN, H .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (04) :1789-1797
[3]   Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women - The Camden study [J].
Chen, XH ;
Scholl, TO ;
Stein, TP .
DIABETES CARE, 2006, 29 (05) :1077-1082
[4]  
CHENG YC, 2008, NEPHROLOGY CARLTON, V14, P65
[5]   MODULATION OF IRON-METABOLISM IN MONOCYTE CELL-LINE U937 BY INFLAMMATORY CYTOKINES - CHANGES IN TRANSFERRIN UPTAKE, IRON HANDLING AND FERRITIN MESSENGER-RNA [J].
FAHMY, M ;
YOUNG, SP .
BIOCHEMICAL JOURNAL, 1993, 296 :175-181
[6]   Serum ferritin as a component of the insulin resistance syndrome [J].
Fernández-Real, JM ;
Ricart-Engel, W ;
Arroyo, E ;
Balançá, R ;
Casamitjana-Abella, R ;
Cabrero, D ;
Fernández-Castañer, M ;
Soler, J .
DIABETES CARE, 1998, 21 (01) :62-68
[7]   Cross-talk between iron metabolism and diabetes [J].
Fernández-Real, JM ;
López-Bermejo, A ;
Ricart, W .
DIABETES, 2002, 51 (08) :2348-2354
[8]   Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study [J].
Forouhi, N. G. ;
Harding, A. H. ;
Allison, M. ;
Sandhu, M. S. ;
Welch, A. ;
Luben, R. ;
Bingham, S. ;
Khaw, K. T. ;
Wareham, N. J. .
DIABETOLOGIA, 2007, 50 (05) :949-956
[9]   Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years -: The data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study [J].
Fumeron, Frederic ;
Tichet, Jean ;
Pean, Franck ;
Marre, Michel ;
Driss, Fatti ;
Grandchamp, Bernard ;
Balkau, Beverley .
DIABETES CARE, 2006, 29 (09) :2090-2094
[10]  
GALLAGHER ML, 2008, NUTR THEIR METABOLIS, P114
1234