The effect of a selective inhibition of potassium channels on the relaxation induced by nitric oxide in the human pregnant myometrium

被引：0
作者：
Modzelewska, B [1 ]
Kleszczewski, T [1 ]
Kostrzewska, A [1 ]
机构：
[1] Med Univ Bialystok, Dept Biophys, PL-15230 Bialystok, Poland
来源：
CELLULAR & MOLECULAR BIOLOGY LETTERS | 2003年 / 8卷 / 01期
关键词：
human myometrium; nitric oxide; K+ channels; apamin;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this study was to investigate whether apamin-sensitive K+ channels play a role in the NO induced relaxation of the human pregnant myometrium. Concentration-response curves for sodium nitroprusside (SNP) (10(-9)-10(-4) M) were constructed in the absence and presence of 10(-8) M apamin and 10(-7) M charybdotoxin (CTX). Preincubation with apamin resulted in a significant attenuation of the relaxation caused by SNP, while pre-treatment with CTX insignificantly decreased the SNP induced relaxation. Our findings suggest that apamin-sensitive K+ channels exist in the human pregnant myometrium and play a role in modulation of the myometrium response to NO donors.
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收藏
页码：69 / 75
页数：7
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