Cu/Fe Catalyzed Intermolecular Oxidative Amination of Benzylic C-H Bonds

被引：36

作者：

Liu, Cong ^{[1
,2
]}

Zhang, Qi ^{[1
]}

Li, Hongbo ^{[1
]}

Guo, Shuangxi ^{[1
]}

Xiao, Bin ^{[2
]}

Deng, Wei ^{[3
]}

Liu, Lei ^{[2
]}

He, Wei ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[3] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 18期

关键词：

benzylic; C H activation; C H amination; Cu catalysis; Fe catalysis; METAL-FREE; AMINES; C(SP(3))-H; AMIDATION; AMIDES;

D O I：

10.1002/chem.201600107

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a Cu/Fe co-catalyzed Ritter-type C-H activation/amination reaction that allows efficient and selective intermolecular functionalization of benzylic C-H bonds. This new reaction is featured by simple reaction conditions, readily available reagents and general substrate scope, allowing facile synthesis of biologically interesting nitrogen containing heterocycles. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis.

引用

页码：6208 / 6212

页数：5

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