Epidemiology of Antibody-Positive Autoimmune Encephalitis in Southwest China: A Multicenter Study

被引:59
作者
Gu, Yixue [1 ]
Zhong, Min [2 ]
He, Liang [3 ]
Li, Wei [4 ,5 ]
Huang, Yuanyuan [6 ]
Liu, Jing [7 ]
Chen, Yangmei [3 ]
Xiao, Zheng [1 ]
机构
[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China
[2] Chongqing Med Univ, Childrens Hosp, Dept Neurol, Chongqing, Peoples R China
[3] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing, Peoples R China
[4] Army Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing, Peoples R China
[5] Army Mil Med Univ, Res Inst Surg, Chongqing, Peoples R China
[6] Army Med Univ, Third Mil Med Univ, Southwest Hosp, Dept Neurol, Chongqing, Peoples R China
[7] Chongqing Three Gorges Cent Hosp, Dept Neurol, Chongqing, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
基金
中国国家自然科学基金;
关键词
autoimmune encephalitis; epidemiology; age; sex; neuronal autoantibodies; CONTACTIN-ASSOCIATED PROTEIN-2; NMDA RECEPTOR ENCEPHALITIS; LIMBIC ENCEPHALITIS; DIAGNOSIS; TITERS; SEX;
D O I
10.3389/fimmu.2019.02611
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In recent years, as an increasing number of neuronal autoantibodies have been detected and used for clinical diagnosis, clinicians have become more aware of autoimmune encephalitis, causing its reported incidence to trend upward over several years. To date, however, there has been no large-scale epidemiological survey of autoimmune encephalitis in adults and children, and its epidemiological characteristics remain unclear. Six main types of antibodies are detected and used to diagnose autoimmune encephalitis in Chongqing, Southwestern China: anti-NMDA receptor antibody, anti-GABA(B) receptor antibody, anti-LGI1 antibody, anti-CASPR2 antibody, anti-AMPA1 receptor antibody, and anti-AMPA2 receptor antibody. From January 2012 to February 2018, 189 patients at six general hospitals in Chongqing were diagnosed with autoimmune encephalitis and were positive for neuronal autoantibodies. In this report, the epidemic situation and the antibody distribution among these patients are analyzed and described in detail. The differences in disease severity among different ages and between the sexes are evaluated, and the correlation between antibody titer and disease severity is also assessed.
引用
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页数:7
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