The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

被引：48
作者：
Castanho, Teresa Costa [1 ,2 ,3 ]
Moreira, Pedro Silva [1 ,2 ,3 ]
Portugal-Nunes, Carlos [1 ,2 ,3 ]
Novais, Ashley [1 ,2 ,3 ]
Costa, Patricio Soares [1 ,2 ,3 ]
Palha, Joana Almeida [1 ,2 ,3 ]
Sousa, Nuno [1 ,2 ,3 ]
Santos, Nadine Correia [1 ,2 ,3 ]
机构：
[1] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal
[2] ICVS 3Bs, PT Govt Associate Lab, P-4710057 Braga, Portugal
[3] Clin Acad Ctr Braga, P-4710057 Braga, Portugal
来源：
BIOLOGICAL PSYCHOLOGY | 2014年 / 103卷
关键词：
Executive function; Memory; Quality of life; Sleep; Nutrition; SERUM-FREE TESTOSTERONE; ENDOGENOUS ESTRADIOL; DEPRESSIVE SYMPTOMS; LUTEINIZING-HORMONE; PROLACTIN PRL; PERFORMANCE; HEALTH; MEMORY; AGE; DHEAS;
D O I：
10.1016/j.biopsycho.2014.08.015
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL,FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：158 / 166
页数：9
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