Iridium-Monodentate Phosphoramidite-Catalyzed Asymmetric Hydrogenation of Substituted Benzophenone N-H Imines

被引：100

作者：

Hou, Guohua ^{[1
]}

Tao, Ran ^{[2
]}

Sun, Yongkui ^{[2
]}

Zhang, Xumu ^{[1
]}

Gosselin, Francis ^{[2
]}

机构：

[1] Rutgers State Univ, Dept Chem, Piscataway, NJ 08854 USA

[2] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 07期

基金：

美国国家卫生研究院;

关键词：

ENANTIOSELECTIVE HYDROGENATION; ARYLBORONIC ACIDS; ARYL KETONES; ARYLATION; DIARYLMETHYLAMINES; LIGANDS; TOSYLARYLIMINES; CETIRIZINE; REAGENTS; ALDIMINES;

D O I：

10.1021/ja909583s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Homogeneous asymmetric hydrogenation of unprotected benzophenone N-H imines 1a-r using 1r-benzyl-N-methyl-MonoPhos as a catalyst provides chiral amines 2a-r in 80-96% yield with enantioselectivities up to 98% ee (18 examples) for ortho-substituted substrates.

引用

页码：2124 / +

页数：3

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