Organocatalytic cascade 1,6-conjugate addition/annulation/tautomerization of functionalized para-quinone methides: Access to chiral 2-amino-4-aryl-4H-chromenes

被引：31

作者：

Duan, Cong ^{[1
]}

Ye, Ling ^{[2
]}

Xu, Wenqin ^{[1
]}

Li, Xinying ^{[1
]}

Chen, Feng ^{[1
]}

Zhao, Zhigang ^{[1
]}

Li, Xuefeng ^{[1
]}

机构：

[1] Southwest Minzu Univ, Coll Chem & Environm Protect Engn, Chengdu 610041, Sichuan, Peoples R China

[2] Southwest Jiaotong Univ, Fac Geosci & Environm Engn, Chengdu 610031, Sichuan, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 08期

基金：

中国国家自然科学基金;

关键词：

pars-Quinone methides; 2-Amino-4-aryl-4H-chromene; Domino reaction; 1,6-Conjugated addition; Enantioselective; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; APOPTOSIS INDUCERS; CONJUGATE ADDITION; ACID-ESTERS; IN-SITU; DERIVATIVES; DISCOVERY; SERIES; 2-AMINO-4H-CHROMENES;

D O I：

10.1016/j.cclet.2017.11.044

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel organocatalytic cascade process initiated by 1,6-conjugated addition has been successfully developed. A range of pharmaceutically active 2-amino-4-aryl-4H-chromenes were readily obtained in high yields (88%-99%) and excellent enantiopurities (86%-99% ee). The functionalized para-Quinone methides (p-OMs) could be facilely obtained. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1273 / 1276

页数：4

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