Highly Regioselective and Chemoselective [3+3] Annulation of Enaminones with ortho-Fluoronitrobenzenenes: Divergent Synthesis of Aposafranones and Their N-Oxides

被引：32

作者：

Chen, Xue-Bing ^{[1
]}

Huang, Shun-Tao ^{[1
]}

Li, Jie ^{[1
]}

Yang, Qi ^{[1
]}

Yang, Li ^{[1
]}

Yu, Fuchao ^{[2
]}

机构：

[1] Honghe Univ, Coll Sci, Mengzi 661199, Yunnan, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650504, Yunnan, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 08期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/acs.orglett.1c00710

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A base-promoted unprecedented strategy for the regioselective and chemoselective divergent synthesis of highly functionalized aposafranones and their N-oxides has been developed from the [3 + 3] annulation of enaminones with o-fluoronitrobenzenenes. This novel synthetic strategy offers an alternative method for the construction of aposafranones and their N-oxides are meaningful in the fields of both biology and organic synthesis. The established protocol explores the annulation scope of enaminones, and it expands the application of nitro-based cyclization.

引用

页码：3032 / 3037

页数：6

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