Silver-Catalyzed, Aldehyde-Induced α-C-H Functionalization of Tetrahydroisoquinolines with Concurrent C-P Bond Formation/N-Alkylation

被引：52

作者：

Hu, Gaobo ^{[1
,2
]}

Chen, Weizhu ^{[1
,2
,4
]}

Ma, Dumei ^{[3
]}

Zhang, Yun ^{[1
,2
]}

Xu, Pengxiang ^{[1
,2
]}

Gao, Yuxing ^{[1
,2
]}

Zhao, Yufen ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China

[3] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem & Biochem Engn, Xiamen 361005, Fujian, Peoples R China

[4] State Ocean Adm, Inst Oceanog 3, Xiamen 361005, Fujian, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 04期

关键词：

DEHYDROGENATIVE COUPLING REACTIONS; AMINOPHOSPHONIC ACIDS; BIOLOGICAL-ACTIVITY; SYNTHETIC METHODS; EFFICIENT; INHIBITORS; PHOSPHONATES; DERIVATIVES; CHEMISTRY; ANALOGS;

D O I：

10.1021/acs.joc.5b02625

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first facile and efficient silver-catalyzed, aldehyde-induced three-component reaction of N-unprotected tetrahydroisoquinolines, aldehydes, and dialkyl phosphonates has been developed, providing a general one-step approach to structurally diverse C1-phosphonylated THIQs accompanied by concurrent C-P bond formation/N-alkylation with remarkable functional group tolerance and excellent regioselectivity for endo products.

引用

页码：1704 / 1711

页数：8

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