The mGlu2/3 receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing

被引：81

作者：

Cartmell, J ^{[1
]}

Monn, JA ^{[1
]}

Schoepp, DD ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Neurosci Res, Indianapolis, IN 46285 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 400卷 / 2-3期

关键词：

glutamate receptor; metabotropic; amphetamine; LY379268; motor activity; stereotypy;

D O I：

10.1016/S0014-2999(00)00423-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have previously reported that the specific group II metabotropic glutamate receptor agonist LY379268 inhibited phencyclidine (PCP)-induced motor activations in rats, but had mixed effects on behaviors produced by amphetamine. Here, LY379268 (1 mg/kg subcutaneous (s.c.)) attenuated amphetamine-induced ambulations and rearing but did not alter amphetamine-evoked fine motor movements. Consistent with a mechanism involving mGlu(2/3) receptors, the inhibitory actions of LY379268 on ambulations and rearing were reversed by LY341495, a mGlu(2/3) receptor antagonist. These data further suggest antipsychotic actions of mGlu(2/3) receptor agonists with a low propensity for extra-pyramidal side effects. (C) 2000 Published by Elsevier Science B.V.

引用

页码：221 / 224

页数：4

共 12 条

[1] D-amphetamine, cocaine and caffeine: a comparative study of acute effects on locomotor activity and behavioural patterns in rats [J].

Antoniou, K ;

Kafetzopoulos, E ;

Papadopoulou-Daifoti, Z ;

Hyphantis, T ;

Marselos, M .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1998, 23 (02) :189-196

[2] DIFFERENTIAL-EFFECTS OF CLASSICAL AND NEWER ANTIPSYCHOTICS ON THE HYPERMOTILITY INDUCED BY 2 DOSE LEVELS OF D-AMPHETAMINE [J].

ARNT, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 283 (1-3) :55-62

[3]

Cartmell J, 1999, J PHARMACOL EXP THER, V291, P161

[4] Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine [J].

Cartmell, J ;

Monn, JA ;

Schoepp, DD .

PSYCHOPHARMACOLOGY, 2000, 148 (04) :423-429

[5] Pharmacology and functions of metabotropic glutamate receptors [J].

Conn, PJ ;

Pin, JP .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :205-237

[6] LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors [J].

Kingston, AE ;

Ornstein, PL ;

Wright, RA ;

Johnson, BG ;

Mayne, NG ;

Burnett, JP ;

Belagaje, R ;

Wu, S ;

Schoepp, DD .

NEUROPHARMACOLOGY, 1998, 37 (01) :1-12

[7] Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats [J].

Moghaddam, B ;

Adams, BW .

SCIENCE, 1998, 281 (5381) :1349-1352

[8] Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors [J].

Monn, JA ;

Valli, MJ ;

Massey, SM ;

Hansen, MM ;

Kress, TJ ;

Wepsiec, JP ;

Harkness, AR ;

Grutsch, JL ;

Wright, RA ;

Johnson, BG ;

Andis, SL ;

Kingston, A ;

Tomlinson, R ;

Lewis, R ;

Griffey, KR ;

Tizzano, JP ;

Schoepp, DD .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (06) :1027-1040

[9] MOLECULAR DIVERSITY OF GLUTAMATE RECEPTORS AND IMPLICATIONS FOR BRAIN-FUNCTION [J].

NAKANISHI, S .

SCIENCE, 1992, 258 (5082) :597-603

[10] PHARMACOLOGY AND PHYSIOLOGY OF STEREOTYPED BEHAVIOR [J].

RANDRUP, A ;

MUNKVAD, I .

JOURNAL OF PSYCHIATRIC RESEARCH, 1974, 11 :1-10

← 1 2 →