Chromatin dynamics and the preservation of genetic information

被引：232
作者：
Downs, Jessica A. [1 ]
Nussenzweig, Michel C.
Nussenzweig, Andre
机构：
[1] Univ Sussex, MRC, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA
[3] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA
来源：
NATURE | 2007年 / 447卷 / 7147期
关键词：
D O I：
10.1038/nature05980
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin - the fibres into which DNA is packaged with a proteinaceous structural polymer - has an important role in initiating, propagating and terminating this cellular response to DNA damage.
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收藏
页码：951 / 958
页数：8
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