Chromatin dynamics and the preservation of genetic information

被引：232

作者：

Downs, Jessica A. ^{[1
]}

Nussenzweig, Michel C.

Nussenzweig, Andre

机构：

[1] Univ Sussex, MRC, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

[3] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE | 2007年 / 447卷 / 7147期

关键词：

D O I：

10.1038/nature05980

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin - the fibres into which DNA is packaged with a proteinaceous structural polymer - has an important role in initiating, propagating and terminating this cellular response to DNA damage.

引用

页码：951 / 958

页数：8

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