C3 Sulfenylation of N-Heteroarenes in Water under Catalyst-Free Conditions

被引：57

作者：

Ravi, Chitrakar ^{[1
]}

Joshi, Abhisek ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] Cent Salt & Marine Chem Res Inst, CSIR, Acad Sci & Innovat Res, GB Marg, Bhavnagar 364002, Gujarat, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 25期

关键词：

Water chemistry; Heterocycles; Sulfur; Catalyst-free; C-H functionalization; H BOND FUNCTIONALIZATION; ARYL SULFONYL HYDRAZIDES; REGIOSELECTIVE SULFENYLATION; ELEMENTAL SULFUR; IMIDAZOHETEROCYCLES; SYSTEM; THIOSULFONATES; INDOLES; HYDROAMINATION; SULPHENYLATION;

D O I：

10.1002/ejoc.201700487

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

method for the catalyst-free C-H sulfenylation of imidazo[1,2-a] pyridines by using sulfonothioates as an odorless thioarylated reagent in aqueous medium was developed. This protocol was used for a variety of substituted imidazo[1,2-a] pyridines with broad functional-group tolerance and was extended to the sulfenylation of indoles and imidazothiazoles. The sulfonothioates were activated exclusively in aqueous medium rather than in an organic solvent, and the feasibility of the process for scale-up studies was demonstrated.

引用

页码：3646 / 3651

页数：6

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