Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis

被引：25
作者：
Wu, Xinle [1 ]
Li, Yang [1 ]
机构：
[1] Amgen Inc, 1120 Vet Blvd, San Francisco, CA 94080 USA
来源：
AGING-US | 2009年 / 1卷 / 12期
关键词：
fibroblast growth factors; FGF19; FGF21; FGF23; aging; diabetes; metabolic diseases; insulin; METABOLIC-ACTIVITY; BETA-KLOTHO; GROWTH; SPECIFICITY; SUPPRESSION; DETERMINES; EXPRESSION; SIGNAL; FAMILY; MODE;
D O I：
10.18632/aging.100108
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
FGF19, FGF21, and FGF23 form a unique subfamily of fibroblast growth factors. Because they contain intra molecular disulfide bonds and show reduced affinity toward heparan sulfate located in the extracellular space, it is thought that, in contrast to other FGFs, they function as endocrine hormones. FGF23 and its co-receptor alpha Klotho are involved in the control of aging, but it is not known if the same holds true for FGF19, which can also signal through alpha Klotho. However, considerable evidence supports a role for FGF19 in controlling various aspects of metabolism. We have recently fully characterized FGF19/FGFR/co-factor interactions and signaling, and in the current manuscript discuss the contribution of the FGF19/FGFR4 axis to bile acid and glucose regulation.
引用
收藏
页码：1023 / 1027
页数：5
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