Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis

被引：25

作者：

Wu, Xinle ^{[1
]}

Li, Yang ^{[1
]}

机构：

[1] Amgen Inc, 1120 Vet Blvd, San Francisco, CA 94080 USA

来源：

AGING-US | 2009年 / 1卷 / 12期

关键词：

fibroblast growth factors; FGF19; FGF21; FGF23; aging; diabetes; metabolic diseases; insulin; METABOLIC-ACTIVITY; BETA-KLOTHO; GROWTH; SPECIFICITY; SUPPRESSION; DETERMINES; EXPRESSION; SIGNAL; FAMILY; MODE;

D O I：

10.18632/aging.100108

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

FGF19, FGF21, and FGF23 form a unique subfamily of fibroblast growth factors. Because they contain intra molecular disulfide bonds and show reduced affinity toward heparan sulfate located in the extracellular space, it is thought that, in contrast to other FGFs, they function as endocrine hormones. FGF23 and its co-receptor alpha Klotho are involved in the control of aging, but it is not known if the same holds true for FGF19, which can also signal through alpha Klotho. However, considerable evidence supports a role for FGF19 in controlling various aspects of metabolism. We have recently fully characterized FGF19/FGFR/co-factor interactions and signaling, and in the current manuscript discuss the contribution of the FGF19/FGFR4 axis to bile acid and glucose regulation.

引用

收藏

页码：1023 / 1027

页数：5

相关论文

共 25 条

[1] Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity [J].

Berglund, Eric D. ;

Li, Candice Y. ;

Bina, Holly A. ;

Lynes, Sara E. ;

Michael, M. Dodson ;

Shanafelt, Armen B. ;

Kharitonenkov, Alexei ;

Wasserman, David H. .

ENDOCRINOLOGY, 2009, 150 (09) :4084-4093

[2] Cellular signaling by fibroblast growth factor receptors [J].

Eswarakumar, VP ;

Lax, I ;

Schlessinger, J .

CYTOKINE & GROWTH FACTOR REVIEWS, 2005, 16 (02) :139-149

[3] Fibroblast growth factor 19 increases metabolic rate I and reverses dietary and leptlin-deficient diabetes [J].

Fu, L ;

John, LM ;

Adams, SH ;

Yu, XX ;

Tomlinson, E ;

Renz, M ;

Williams, PM ;

Soriano, R ;

Corpuz, R ;

Moffat, B ;

Vandlen, R ;

Simmons, L ;

Foster, J ;

Stephan, JP ;

Tsai, SP ;

Stewart, TA .

ENDOCRINOLOGY, 2004, 145 (06) :2594-2603

[4] Actions and mode of actions of FGF19 subfamily members [J].

Fukumoto, Seiji .

ENDOCRINE JOURNAL, 2008, 55 (01) :23-31

[5] Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members [J].

Goetz, Regina ;

Beenken, Andrew ;

Ibrahimi, Omar A. ;

Kalinina, Juliya ;

Olsen, Shaun K. ;

Eliseenkova, Anna V. ;

Xu, ChongFeng ;

Neubert, Thomas A. ;

Zhang, Fuming ;

Linhardt, Robert J. ;

Yu, Xijie ;

White, Kenneth E. ;

Inagaki, Takeshi ;

Kliewer, Steven A. ;

Yamamoto, Masaya ;

Kurosu, Hiroshi ;

Ogawa, Yasushi ;

Kuro-o, Makoto ;

Lanske, Beate ;

Razzaque, Mohammed S. ;

Mohammadi, Moosa .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (09) :3417-3428

[6] Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis [J].

Holt, JA ;

Luo, GZ ;

Billin, AN ;

Bisi, J ;

McNeill, YY ;

Kozarsky, KF ;

Donahee, M ;

Wang, DY ;

Mansfield, TA ;

Kliewer, SA ;

Goodwin, B ;

Jones, SA .

GENES & DEVELOPMENT, 2003, 17 (13) :1581-1591

[7] FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet-induced fatty liver [J].

Huang, Xinqiang ;

Yang, Chaofeng ;

Luo, Yongde ;

Jin, Chengliu ;

Wang, Fen ;

McKeehan, Wallace L. .

DIABETES, 2007, 56 (10) :2501-2510

[8] Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis [J].

Inagaki, T ;

Choi, M ;

Moschetta, A ;

Peng, L ;

Cummins, CL ;

McDonald, JG ;

Luo, G ;

Jones, SA ;

Goodwin, B ;

Richardson, JA ;

Gerard, RD ;

Repa, JJ ;

Mangelsdorf, DJ ;

Kliewer, SA .

CELL METABOLISM, 2005, 2 (04) :217-225

[9] Molecular cloning and expression analyses of mouse ßklotho, which encodes a novel Klotho family protein [J].

Ito, S ;

Kinoshita, S ;

Shiraishi, N ;

Nakagawa, S ;

Sekine, S ;

Fujimori, T ;

Nabeshima, Y .

MECHANISMS OF DEVELOPMENT, 2000, 98 (1-2) :115-119

[10] Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho [J].

Ito, S ;

Fujimori, T ;

Furuya, A ;

Satoh, J ;

Nabeshima, Y ;

Nabeshima, Y .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (08) :2202-2208