Reflectance Confocal Microscopy of Aging Skin and Skin Cancer

被引：27
|
作者：
Guida, Stefania [1 ,2 ]
Pellacani, Giovanni [1 ,2 ,4 ]
Ciardo, Silvana [1 ,2 ]
Longo, Caterina [1 ,2 ,3 ]
机构：
[1] Univ Modena & Reggio Emilia, Dept Surg Med Dent, Dermatol Unit, Via Pozzo 71, I-411125 Modena, Italy
[2] Univ Modena & Reggio Emilia, Morphol Sci Related Transplant Oncol & Regenerat, Via Pozzo 71, I-411125 Modena, Italy
[3] Azienda Unita Sanit Locale Ist Ricovero & Cura Ca, Ctr Oncol & Alta Tecnol Diagnost, Reggio Emilia, Italy
[4] Sapienza Univ Rome, Dermatol Unit, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Rome, Italy
来源：
DERMATOLOGY PRACTICAL & CONCEPTUAL | 2021年 / 11卷 / 03期
关键词：
Skin aging; skin cancer; collagen; blood vessels; reflectance confocal microscopy; SCANNING LASER MICROSCOPY; POOLED-ANALYSIS; EXTRACELLULAR-MATRIX; SUN EXPOSURE; VARIANTS; MC1R; MELANOMA; RISK;
D O I：
10.5826/dpc.1103a68
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Skin aging is a complex process that causes morphologic variations. Some of these variations have been hypothesized to be involved in skin cancer development. This paper reviews current knowledge of the features of aged skin as seen with reflectance confocal microscopy (RCM). Basic principles of the technique are described, and the RCM features of healthy skin and skin cancer are briefly discussed. Moreover, the RCM features at different layers of young and elderly skin are described, as are the variations that occur with passing years and in relation to sun exposure that contribute to photoaging and the development of skin cancer. RCM enables the noninvasive evaluation, at quasi-histologic resolution, of aging-related skin changes, some of which are shared with skin cancer; this ability helps avoid skin biopsy. Further research is needed to understand the relation between skin aging and skin cancer development.
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页数：8
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