Severe immune-related hyperthermia followed by immune-related pneumonitis with PD-1 inhibitor (sintilimab) in small cell lung cancer: A case report

被引：12
|
作者：
Li, Yi-hui [1 ]
Zhou, Yang [1 ]
Liu, Yuan-yuan [1 ]
Zhang, Guang-ju [1 ]
Xiao, Lei [1 ]
Li, Na [1 ]
Qin, Hai-feng [2 ]
Wang, Jian-gong [1 ]
Zhang, Li [3 ]
机构：
[1] Tangshan Peoples Hosp, Dept Multimodal Therapy Oncol, 65 Shengli Rd, Tangshan 063000, Hebei, Peoples R China
[2] Nanyuan Dist 302 Hosp PLA, Dept Pulm Neoplasm Internal Med, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Resp, Beijing, Peoples R China
来源：
THORACIC CANCER | 2021年 / 12卷 / 11期
关键词：
small cell lung cancer; immune checkpoint inhibitors; sintilimab; hyperthermia; immune‐ related pneumonitis; ADVERSE EVENTS; PROFILES;
D O I：
10.1111/1759-7714.13967
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune checkpoint inhibitors (ICIs) have achieved prominent efficacy in the treatment of numerous cancers, which is the most significant breakthrough in cancer therapy in recent years. However, ICIs are associated with a series of immune-related adverse events (irAEs). Pneumonitis is an uncommon but potentially fatal irAE. In the case reported here, a patient with advanced small cell lung cancer (SCLC) had rapid progression of disease following chemotherapy and received ICIs. The patient experienced severe immune-related hyperthermia followed by immune-related pneumonitis. Fortunately, a good clinical response was achieved after the patient received corticosteroids and tocilizumab.
引用
收藏
页码：1780 / 1783
页数：4
相关论文
共 50 条
  • [1] Association of immune-related pneumonitis with the efficacy of PD-1/PD-L1 inhibitors in non-small cell lung cancer
    Cui, Pengfei
    Huang, Di
    Wu, Zhaozhen
    Tao, Haitao
    Zhana, Sujie
    Ma, Junxun
    Liu, Zhefeng
    Wang, Jinliang
    Huang, Ziwei
    Chen, Shixue
    Zheng, Xuan
    Hu, Yi
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2020, 12
  • [2] A case report of advanced thymoma re-treated with PD-1 inhibitor after initial immune-related pneumonitis
    Zhang, Yao
    Li, Wenhua
    Hu, Xichun
    Zhang, Jian
    ANNALS OF PALLIATIVE MEDICINE, 2021, 10 (09) : 10083 - 10090
  • [3] Sequential severe immune-related adverse events induced by PD-1 inhibitor: a case report and literature review
    Xia, Jinxiong
    Wen, Yingmei
    Xiao, Mengxia
    Ye, Dafu
    Gao, Yanjun
    Tang, Dongling
    Zhang, Xiuyun
    Chen, Jinling
    Li, Qingqing
    Yao, Yi
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [4] Sintilimab for the treatment of lung adenocarcinoma-induced immune-related hypophysitis: a case report
    Wang, Ming-xing
    Liu, Ai-xin
    Sun, Qing-ming
    Dong, Wan-hui
    FRONTIERS IN IMMUNOLOGY, 2025, 16
  • [5] Lethal Immune-Related Pneumonitis after Durvalumab Therapy for Small Cell Lung Cancer: A First Case in China
    Li, Qian
    Liu, Mei
    Liu, Yunxia
    Shi, Feng
    Yuan, Shan
    Di, Guojie
    Jin, Haobin
    Shi, Yaru
    Zhang, Wen
    Yang, Zhe
    CASE REPORTS IN ONCOLOGY, 2024, 17 (01): : 673 - 680
  • [6] Identification of a prognostic immune-related signature for small cell lung cancer
    Xie, Qi
    Chu, Huili
    Yi, Jian
    Yu, Hui
    Gu, Tiantian
    Guan, Yaping
    Liu, Xiaolin
    Liang, Jing
    Li, Yan
    Wang, Jun
    CANCER MEDICINE, 2021, 10 (24): : 9115 - 9128
  • [7] Development and validation of a nomogram for predicting immune-related pneumonitis after sintilimab treatment
    Hong, Baohui
    Chen, Rong
    Zheng, Caiyun
    Liu, Maobai
    Yang, Jing
    CANCER MEDICINE, 2024, 13 (03):
  • [8] Immune Check Point Inhibitors and Immune-Related Adverse Events in Small Cell Lung Cancer
    Hou, Wanting
    Zhou, Xiaohan
    Yi, Cheng
    Zhu, Hong
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [9] Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor-A Report of 3 Cases
    Herrmann, Sandra M.
    Alexander, Mariam P.
    Romero, Michael F.
    Zand, Ladan
    KIDNEY MEDICINE, 2020, 2 (05) : 657 - 662
  • [10] Successful Retreatment Using Pembrolizumab for Non-small-cell Lung Cancer After Severe Immune-related Hepatitis: A Case Report
    Kobayashi, Keigo
    Nakachi, Ichiro
    Mitsuishi, Akifumi
    Arai, Daisuke
    Sakurai, Kaori
    Masaki, Katsunori
    Chiyotani, Atsushi
    Takahashi, Hidenori
    Tahara, Toshiyuki
    Soejima, Kenzo
    CLINICAL LUNG CANCER, 2020, 21 (01) : E30 - E32
12345