Pathophysiology of Hemorrhage as It Relates to the Warfighter

被引：11

作者：

Hinojosa-Laborde, Carmen ^{[1
]}

Hudson, Ian L. ^{[1
]}

Ross, Evan ^{[1
]}

Xiang, Lusha ^{[1
]}

Ryan, Kathy L. ^{[1
]}

机构：

[1] US Army, Inst Surg Res, San Antonio, TX 78234 USA

来源：

PHYSIOLOGY | 2022年 / 37卷 / 03期

关键词：

Battlefield; hemorrhage; prolonged casualty care; trauma; WHOLE-BLOOD RESUSCITATION; MITOCHONDRIAL COMPLEX-III; TRANS-SODIUM CROCETINATE; ACUTE KIDNEY INJURY; TRANEXAMIC ACID; VALPROIC ACID; TRAUMA PATIENTS; CELL-DEATH; INCREASES SURVIVABILITY; SUPEROXIDE-PRODUCTION;

D O I：

10.1152/physiol.00028.2021

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Saving lives of wounded military warfighters often depends on the ability to resolve or mitigate the pathophysiology of hemorrhage, specifically diminished oxygen delivery to vital organs that leads to multiorgan failure and death. However, caring for hemorrhaging patients on the battlefield presents unique challenges that extend beyond applying a tourniquet and giving a blood transfusion, especially when battlefield care must be provided for a prolonged period. This review describes these challenges and potential strategies for treating hemorrhage on the battlefield in a prolonged casualty care situation.

引用

页码：141 / 153

页数：13

共 162 条

[1] Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation [J].

Abramov, Andrey Y. ;

Scorziello, Antonella ;

Duchen, Michael R. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (05) :1129-1138

[2]

[Anonymous], 2017, Reuters

[3] EFFECT OF HYPOXIA UPON INTRACELLULAR CALCIUM-CONCENTRATION OF HUMAN ENDOTHELIAL-CELLS [J].

ARNOULD, T ;

MICHIELS, C ;

ALEXANDRE, I ;

REMACLE, J .

JOURNAL OF CELLULAR PHYSIOLOGY, 1992, 152 (01) :215-221

[4] The mitochondrial permeability transition pore and ischemia-reperfusion injury [J].

Baines, Christopher P. .

BASIC RESEARCH IN CARDIOLOGY, 2009, 104 (02) :181-188

[5] Pathophysiology of Acute Kidney Injury [J].

Basile, David P. ;

Anderson, Melissa D. ;

Sutton, Timothy A. .

COMPREHENSIVE PHYSIOLOGY, 2012, 2 (02) :1303-1353

[6] Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects [J].

Battelli, Maria Giulia ;

Polito, Letizia ;

Bortolotti, Massimo ;

Bolognesi, Andrea .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016

[7] The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production [J].

Bell, Eric L. ;

Klimova, Tatyana A. ;

Eisenbart, James ;

Moraes, Carlos T. ;

Murphy, Michael P. ;

Budinger, G. R. Scott ;

Chandel, Navdeep S. .

JOURNAL OF CELL BIOLOGY, 2007, 177 (06) :1029-1036

[8]

Bellamy R, 1996, CRIT CARE MED, V24, pS24

[9] Pyroptosis: host cell death and inflammation [J].

Bergsbaken, Tessa ;

Fink, Susan L. ;

Cookson, Brad T. .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (02) :99-109

[10] Valproic acid decreases resuscitation requirements after hemorrhage in a prolonged damage-control resuscitation model [J].

Biesterveld, Ben E. ;

Williams, Aaron M. ;

Kemp, Michael T. ;

Wakam, Glenn K. ;

Siddiqui, Ali Z. ;

O'Connell, Rachel L. ;

Shamshad, Alizeh ;

Chtraklin, Kiril ;

Bhatti, Umar F. ;

Li, Yongqing ;

Alam, Hasan B. .

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 2020, 89 (04) :752-760

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