Ectopic bone formation with joint impingement after posterior lumbar fusion with rhBMP-2

被引：7

作者：

Bannwarth, M. ^{[1
]}

Kleiber, J. C. ^{[1
]}

Marlier, B. ^{[1
]}

Eap, C. ^{[1
]}

Duntze, J. ^{[1
]}

Litre, C. F. ^{[1
]}

机构：

[1] Reims Univ Hosp, Neurosurg Dept, Reims, France

来源：

ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH | 2016年 / 102卷 / 02期

关键词：

Recombinant human bone morphogenetic protein-2; Spinal fusion; Complications; MORPHOGENETIC PROTEIN-2; COMPLICATIONS; OUTCOMES;

D O I：

10.1016/j.otsr.2015.11.013

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Recombinant human bone morphogenetic protein-2 (rhBMP-2) was recently licensed for local administration during posterior lumbar fusion. In this indication, considerable uncertainty remains about the nature and mechanisms of the many adverse effects of rhBMP-2, such as ectopic bone formation. We report a case of ectopic bone formation with impingement on a facet joint and incapacitating low back pain after minimally invasive transforaminal L5-S1 interbody fusion with local application of rhBMP-2 (InductOs). Revision surgery was eventually performed to alleviate the symptoms by removing the ectopic bone. Caution is in order regarding the use of rhBMP-2 during posterior lumbar fusion. Every effort should be made to minimise the risk of complications. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：255 / 256

页数：2

共 18 条

[1] Six-Year Outcomes of Anterior Lumbar Interbody Arthrodesis with Use of Interbody Fusion Cages and Recombinant Human Bone Morphogenetic Protein-2 [J].