The IntAct molecular interaction database in 2010

被引：479

作者：

Aranda, B. ^{[1
]}

Achuthan, P. ^{[1
]}

Alam-Faruque, Y. ^{[1
]}

Armean, I.

Bridge, A. ^{[2
]}

Derow, C. ^{[1
]}

Feuermann, M. ^{[2
]}

Ghanbarian, A. T. ^{[1
]}

Kerrien, S. ^{[1
]}

Khadake, J. ^{[1
]}

Kerssemakers, J. ^{[1
]}

Leroy, C. ^{[1
]}

Menden, M. ^{[1
]}

Michaut, M. ^{[1
]}

Montecchi-Palazzi, L. ^{[1
]}

Neuhauser, S. N. ^{[1
]}

Orchard, S. ^{[1
]}

Perreau, V. ^{[3
]}

Roechert, B. ^{[2
]}

van Eijk, K. ^{[1
]}

Hermjakob, H. ^{[1
]}

机构：

[1] EBI, EMBL Outstn, Cambridge CB10 1SD, England

[2] Swiss Inst Bioinformat Geneva, Geneva, Switzerland

[3] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

关键词：

PROTEIN; RESOURCE; ARCHIVE; TEXT;

D O I：

10.1093/nar/gkp878

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IntAct is an open-source, open data molecular interaction database and toolkit. Data is abstracted from the literature or from direct data depositions by expert curators following a deep annotation model providing a high level of detail. As of September 2009, IntAct contains over 200.000 curated binary interaction evidences. In response to the growing data volume and user requests, IntAct now provides a two-tiered view of the interaction data. The search interface allows the user to iteratively develop complex queries, exploiting the detailed annotation with hierarchical controlled vocabularies. Results are provided at any stage in a simplified, tabular view. Specialized views then allows 'zooming in' on the full annotation of interactions, interactors and their properties. IntAct source code and data are freely available at http://www.ebi.ac.uk/intact.

引用

页码：D525 / D531

页数：7

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