Correlation Analysis of Anti-SARS-CoV-2 RBD IgG and Neutralizing Antibody against SARS-CoV-2 Omicron Variants after Vaccination

被引：23

作者：

Takheaw, Nuchjira ^{[1
,2
]}

Liwsrisakun, Chalerm ^{[3
]}

Chaiwong, Warawut ^{[3
]}

Laopajon, Witida ^{[1
,2
]}

Pata, Supansa ^{[1
,2
]}

Inchai, Juthamas ^{[3
]}

Duangjit, Pilaiporn ^{[3
]}

Pothirat, Chaicharn ^{[3
]}

Bumroongkit, Chaiwat ^{[3
]}

Deesomchok, Athavudh ^{[3
]}

Theerakittikul, Theerakorn ^{[3
]}

Limsukon, Atikun ^{[3
]}

Tajarernmuang, Pattraporn ^{[3
]}

Niyatiwatchanchai, Nutchanok ^{[3
]}

Trongtrakul, Konlawij ^{[3
]}

Kasinrerk, Watchara ^{[1
,2
]}

机构：

[1] Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, Div Clin Immunol, Chiang Mai 50200, Thailand

[2] Chiang Mai Univ, Natl Sci & Technol Dev Agcy, Biomed Technol Res Ctr, Natl Ctr Genet Engn & Biotechnol,Fac Associated M, Chiang Mai 50200, Thailand

[3] Chiang Mai Univ, Fac Med, Dept Internal Med, Div Pulm Crit Care & Allergy, Chiang Mai 50200, Thailand

来源：

DIAGNOSTICS | 2022年 / 12卷 / 06期

关键词：

COVID-19; SARS-CoV-2; variants of concern; Omicron variant; vaccine;

D O I：

10.3390/diagnostics12061315

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Various vaccines have been developed to control the COVID-19 pandemic, but the available vaccines were developed using ancestral SARS-CoV-2 wild-type (WT) strains. Commercial anti-SARS-CoV-2 receptor binding domain (RBD) antibody assays have been established and employed for validation of vaccine efficacy. However, these assays were developed before the SARS-CoV-2 variants of concern (VOCs) emerged. It is unclear whether anti-RBD IgG levels can predict immunity against VOCs. In this study, we determined the correlations between the levels of anti-RBD IgG and neutralizing antibodies (NAbs) against SARS-CoV-2 variants in vaccinated subjects. After vaccination, 100% of subjects showed an anti-RBD IgG response, whereas 82, 79, 30, 75, and 2% showed NAb responses against WT, Alpha, Beta, Delta, and Omicron variants, respectively. A high correlation was observed between anti-RBD IgG and NAbs against WT, Alpha, Beta, and Delta, but not so for the Omicron NAbs. Among subjects with high levels of anti-RBD IgG, 93, 93, 71, 93, and 0% of them had NAbs against WT, Alpha, Beta, Delta, and Omicron variants, respectively. These results indicate that anti-RBD IgG levels cannot be used as a predictor for the presence of NAbs against the globally dominant SARS-CoV-2 Omicron variant.

引用

页数：9

共 29 条

[1] Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate [J].

Addetia, Amin ;

Crawford, Katharine H. D. ;

Dingens, Adam ;

Zhu, Haiying ;

Roychoudhury, Pavitra ;

Huang, Meei-Li ;

Jerome, Keith R. ;

Bloom, Jesse D. ;

Greninger, Alexander L. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (11)

[2] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[3] Coronavirus Disease 2019 Vaccine-Breakthrough Infections Requiring Hospitalization in Mayo Clinic Florida Through August 2021 [J].

Bosch, Wendelyn ;

Cowart, Jennifer B. ;

Bhakta, Shivang ;

Carter, Rickey E. ;

Wadei, Hani M. ;

Shah, Sadia Z. ;

Sanghavi, Devang K. ;

Pollock, Benjamin D. ;

Neville, Matthew R. ;

Oman, Sven P. ;

Speicher, Leigh ;

Scindia, Ameya D. ;

Matson, Mark W. ;

Moreno Franco, Pablo .

CLINICAL INFECTIOUS DISEASES, 2022, 75 (01) :E892-E894

[4] HEAVILY MUTATED OMICRON VARIANT PUTS SCIENTISTS ON ALERT [J].

Callaway, Ewen .

NATURE, 2021, 600 (7887) :21-21

[5] Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant-Associated Receptor Binding Domain (RBD) Mutations on the Susceptibility to Serum Antibodies Elicited by Coronavirus Disease 2019 (COVID-19) Infection or Vaccination [J].

Chen, Lin-Lei ;

Lu, Lu ;

Choi, Charlotte Yee-Ki ;

Cai, Jian-Piao ;

Tsoi, Hoi-Wah ;

Chu, Allen Wing-Ho ;

Ip, Jonathan Daniel ;

Chan, Wan-Mui ;

Zhang, Ricky Ruiqi ;

Zhang, Xiaojuan ;

Tam, Anthony Raymond ;

Lau, Daphne Pui-Ling ;

To, Wing-Kin ;

Que, Tak-Lun ;

Yip, Cyril Chik-Yan ;

Chan, Kwok-Hung ;

Cheng, Vincent Chi-Chung ;

Yuen, Kwok-Yung ;

Hung, Ivan Fan-Ngai ;

To, Kelvin Kai-Wang .

CLINICAL INFECTIOUS DISEASES, 2022, 74 (09) :1623-1630

[6] Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination [J].

Cheng, Samuel M. S. ;

Mok, Chris Ka Pun ;

Leung, Yonna W. Y. ;

Ng, Susanna S. ;

Chan, Karl C. K. ;

Ko, Fanny W. ;

Chen, Chunke ;

Yiu, Karen ;

Lam, Bosco H. S. ;

Lau, Eric H. Y. ;

Chan, Ken K. P. ;

Luk, Leo L. H. ;

Li, John K. C. ;

Tsang, Leo C. H. ;

Poon, Leo L. M. ;

Hui, David S. C. ;

Peiris, Malik .

NATURE MEDICINE, 2022, 28 (03) :486-+

[7] Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron [J].

Cui, Zhen ;

Liu, Pan ;

Wang, Nan ;

Wang, Lei ;

Fan, Kaiyue ;

Zhu, Qianhui ;

Wang, Kang ;

Chen, Ruihong ;

Feng, Rui ;

Jia, Zijing ;

Yang, Minnan ;

Xu, Ge ;

Zhu, Boling ;

Fu, Wangjun ;

Chu, Tianming ;

Feng, Leilei ;

Wang, Yide ;

Pei, Xinran ;

Yang, Peng ;

Xie, Xiaoliang Sunney ;

Cao, Lei ;

Cao, Yunlong ;

Wang, Xiangxi .

CELL, 2022, 185 (05) :860-+

[8] SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses [J].

Dejnirattisai, Wanwisa ;

Huo, Jiandong ;

Zhou, Daming ;

Zahradnik, Jiri ;

Supasa, Piyada ;

Liu, Chang ;

Duyvesteyn, Helen M. E. ;

Ginn, Helen M. ;

Mentzer, Alexander J. ;

Tuekprakhon, Aekkachai ;

Nutalai, Rungtiwa ;

Wang, Beibei ;

Dijokaite, Aiste ;

Khan, Suman ;

Avinoam, Ori ;

Bahar, Mohammad ;

Skelly, Donal ;

Adele, Sandra ;

Johnson, Sile Ann ;

Amini, Ali ;

Ritter, Thomas G. ;

Mason, Chris ;

Dold, Christina ;

Pan, Daniel ;

Assadi, Sara ;

Bellass, Adam ;

Omo-Dare, Nicola ;

Koeckerling, David ;

Flaxman, Amy ;

Jenkin, Daniel ;

Aley, Parvinder K. ;

Voysey, Merryn ;

Clemens, Sue Ann Costa ;

Naveca, Felipe Gomes ;

Nascimento, Valdinete ;

Nascimento, Fernanda ;

da Costa, Cristiano Fernandes ;

Resende, Paola Cristina ;

Pauvolid-Correa, Alex ;

Siqueira, Marilda M. ;

Baillie, Vicky ;

Serafin, Natali ;

Kwatra, Gaurav ;

Da Silva, Kelly ;

Madhi, Shabir A. ;

Nunes, Marta C. ;

Malik, Tariq ;

Openshaw, Peter J. M. ;

Baillie, J. Kenneth ;

Semple, Malcolm G. .

CELL, 2022, 185 (03) :467-+

[9]

Guiomar R, 2021, medRxiv, DOI [10.1101/2021.12.10.21267607, 10.1101/2021.12.10.21267607, DOI 10.1101/2021.12.10.21267607]

[10] Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action [J].

Heinz, Franz X. ;

Stiasny, Karin .

NPJ VACCINES, 2021, 6 (01)

← 1 2 3 →