Circulating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort

被引：17

作者：

Cairat, Manon ^{[1
]}

Rinaldi, Sabina ^{[1
]}

Navionis, Anne-Sophie ^{[1
]}

Romieu, Isabelle ^{[2
]}

Biessy, Carine ^{[1
]}

Viallon, Vivian ^{[1
]}

Olsen, Anja ^{[3
,4
]}

Tjonneland, Anne ^{[3
,5
]}

Fournier, Agnes ^{[6
]}

Severi, Gianluca ^{[6
,7
]}

Kvaskoff, Marina ^{[6
]}

Fortner, Renee T. ^{[8
]}

Kaaks, Rudolf ^{[8
]}

Aleksandrova, Krasimira ^{[9
,10
]}

Schulze, Matthias B. ^{[11
,12
]}

Masala, Giovanna ^{[13
]}

Tumino, Rosario ^{[14
]}

Sieri, Sabina ^{[15
]}

Grasso, Chiara ^{[16
]}

Mattiello, Amalia ^{[17
]}

Gram, Inger T. ^{[18
]}

Olsen, Karina Standahl ^{[18
]}

Agudo, Antonio ^{[19
,20
]}

Etxezarreta, Pilar Amiano ^{[21
,22
,23
]}

Sanchez, Maria-Jose ^{[23
,24
,25
,26
]}

Santiuste, Carmen ^{[23
,27
]}

Barricarte, Aurelio ^{[23
,28
,29
]}

Monninkhof, Evelyn ^{[30
]}

Hiensch, Anouk E. ^{[30
]}

Muller, David ^{[31
]}

Merritt, Melissa A. ^{[31
,32
]}

Travis, Ruth C. ^{[33
]}

Weiderpass, Elisabete ^{[1
]}

Gunter, Marc J. ^{[1
]}

Dossus, Laure ^{[1
]}

机构：

[1] WHO, Nutr & Metab Branch, Int Agcy Res Canc, 150 Tours Albert Thomas, F-69372 Lyon 08, France

[2] Natl Inst Publ Hlth, Ctr Populat Hlth Res, Mexico City, Morelos, Mexico

[3] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[4] Univ Aarhus, Dept Publ Hlth, Aarhus, Denmark

[5] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Copenhagen, Denmark

[6] Univ Paris Saclay, CESP UMR1018, Equipe Exposome & Heredite, INSERM,UVSQ,Gustave Roussy, F-94805 Villejuif, France

[7] Univ Florence, Dept Stat Comp Sci & Applicat DISIA, Florence, Italy

[8] German Canc Res Ctr DFKZ, Div Canc Epidemiol, Heidelberg, Germany

[9] Leibniz Inst Prevent Res & Epidemiol BIPS, Dept Epidemiol Methods & Etiol Res, Bremen, Germany

[10] Univ Bremen, Fac Human & Hlth Sci, Bremen, Germany

[11] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[12] Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany

[13] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[14] Hyblean Assoc Epidemiol Res AIRE ONLUS, Ragusa, Italy

[15] Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Via Venezian, Milan, Italy

[16] Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy

[17] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[18] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[19] Catalan Inst Oncol ICO, Unit Nutr & Canc, Lhospitalet De Llobregat, Spain

[20] Bellvitge Biomed Res Inst IDIBELL, Epidemiol Publ Hlth Prevent & Palliat Care Progra, Nutr & Canc Grp, Lhospitalet De Llobregat, Spain

[21] Basque Govt, Minist Hlth, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian, Spain

[22] Biodonostia Hlth Res Inst, Epidemiol Chron & Communicable Dis Grp, San Sebastian, Spain

[23] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain

[24] Escuela Andaluza Salud Publ EASP, Granada, Spain

[25] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain

[26] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[27] Murcia Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia, Spain

[28] Navarra Publ Hlth Inst, Pamplona, Spain

[29] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[30] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[31] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[32] Univ Hawaii, Canc Ctr, Canc Epidemiol Program, 701 Ilalo St, Honolulu, HI 96813 USA

[33] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 0NR, England

来源：

BMC MEDICINE | 2022年 / 20卷 / 01期

基金：

英国医学研究理事会; 瑞典研究理事会;

关键词：

Breast cancer; Inflammation; Biomarkers; Menopausal status; Anthropometry; C-REACTIVE PROTEIN; ADIPONECTIN; LEPTIN; WOMEN; ASSOCIATION; VALIDITY; WEIGHT; INDEX;

D O I：

10.1186/s12916-022-02319-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-alpha, interferon-gamma and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. Methods Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. Results Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)]. Conclusions Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.

引用

页数：14

共 40 条

[1] Biomarkers of inflammation and breast cancer risk: a case-control study nested in the EPIC-Varese cohort
Agnoli, Claudia
Grioni, Sara
Pala, Valeria
Allione, Alessandra
Matullo, Giuseppe
Di Gaetano, Cornelia
Tagliabue, Giovanna
Sieri, Sabina
Krogh, Vittorio
[J]. SCIENTIFIC REPORTS, 2017, 7
[2] Baseline C-Reactive Protein Is Associated With Incident Cancer and Survival in Patients With Cancer
Allin, Kristine H.
Bojesen, Stig E.
Nordestgaard, Borge G.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (13) : 2217 - 2224
[3] [Anonymous], 2007, IARC Monographs on the Evaluation of carcinogenic risk to humans, V90
[4] Leptin and ovarian folliculogenesis: Implications for ovulation induction and ART outcomes
Brannian, JD
Hansen, KA
[J]. SEMINARS IN REPRODUCTIVE MEDICINE, 2002, 20 (02) : 103 - 112
[5] Calle EE, 1996, LANCET, V347, P1713, DOI 10.1016/S0140-6736(96)90806-5
[6] Circulating C-Reactive Protein and Breast Cancer Risk-Systematic Literature Review and Meta-analysis of Prospective Cohort Studies
Chan, Doris S. M.
Bandera, Elisa V.
Greenwood, Darren C.
Norat, Teresa
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2015, 24 (10) : 1439 - 1449
[7] Temporal reliability of cytokines and growth factors in EDTA plasma
Clendenen T.V.
Arslan A.A.
Lokshin A.E.
Idahl A.
Hallmans G.
Koenig K.L.
Marrangoni A.M.
Nolen B.M.
Ohlson N.
Zeleniuch-Jacquotte A.
Lundin E.
[J]. BMC Research Notes, 3 (1)
[8] The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study
Cust, Anne E.
Stocks, Tanja
Lukanova, Annekatrin
Lundin, Eva
Hallmans, Goran
Kaaks, Rudolf
Jonsson, Hayenkan
Stattin, Par
[J]. BREAST CANCER RESEARCH AND TREATMENT, 2009, 113 (03) : 567 - 576
[9] Inflammation and breast cancer - Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression
DeNardo, David G.
Coussens, Lisa M.
[J]. BREAST CANCER RESEARCH, 2007, 9 (04):
[10] Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmo Diet and Cancer Cohort
Dias, Joana A.
Fredrikson, Gunilla N.
Ericson, Ulrika
Gullberg, Bo
Hedblad, Bo
Engstrom, Gunnar
Borgquist, Signe
Nilsson, Jan
Wirfalt, Elisabet
[J]. PLOS ONE, 2016, 11 (07):

← 1 2 3 4 →