Glycated albumin is not significantly correlated with body mass index in patients with acute-onset type 1 diabetes

Background: No previous reports have clarified the relationship between glycated albumin (GA) and BMI in patients with acute-onset type 1 diabetes. Methods: We conducted a cross-sectional study evaluating the correlation between GA and BMI in 209 patients with acute-onset type 1 diabetes and in 159 patients with type 2 diabetes who were designated as the control group. The correlation between fasting serum C-peptide immunoreactivity (CPR) and GA or BMI was also evaluated to clarify the impact of insulin secretion capacity on the relationship between GA and BMI. Results: GA was significantly inversely correlated with BMI in patients with type 2 diabetes (r = -0.317, p < 0.001) but not in patients with type I diabetes (r = 0.031, p = NS). In patients with type 2-diabetes, GA was significantly inversely correlated with fasting CPR, and BMI was significantly correlated with fasting CPR. In patients with type 1 diabetes, GA was significantly inversely correlated with fasting CPR (r = -0.291, p < 0.001), but BMI was not correlated with fasting CPR (r = -0.010, p = NS). Conclusions: Unlike in patients with type 2 diabetes, GA was not significantly correlated with BMI in patients with acute-onset type 1 diabetes. (C) 2014 Elsevier B.V. All rights reserved.