Adherence of Streptococcus pneumoniae to human bronchial epithelial cells (BEAS-2B)

被引：52
作者：
Adamou, JE [1 ]
Wizemann, TM [1 ]
Barren, P [1 ]
Langermann, S [1 ]
机构：
[1] Medimmune Inc, Dept Immunol & Mol Genet, Gaithersburg, MD 20878 USA
来源：
INFECTION AND IMMUNITY | 1998年 / 66卷 / 02期
关键词：
D O I：
10.1128/IAI.66.2.820-822.1998
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pneumococcal adherence to alveolar epithelial cells and nasopharyngeal epithelial cells has been well characterized. However, the interaction of Streptococcus pneumoniae with bronchial epithelial cells has not been studied. We have now shown that pneumococci bind specifically to a human bronchial epithelial cell line (BEAS-2B cells). Pneumococci adhered to BEAS-2B cells in a time-and dose-dependent manner. These results suggest that the bronchial epithelium may serve as an additional site of attachment for pneumococci and demonstrate the utility of the BEAS-2B cell line for studying mechanisms of pneumococcal infection.
引用
收藏
页码：820 / 822
页数：3
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