A human tissue-specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence

被引：100

作者：

Chatsirisupachai, Kasit ^{[1
]}

Palmer, Daniel ^{[1
]}

Ferreira, Susana ^{[1
]}

de Magalhaes, Joao Pedro ^{[1
]}

机构：

[1] Univ Liverpool, Inst Ageing & Chron Dis, Integrat Genom Ageing Grp, William Duncan Bldg,Room 281,6 West Derby St, Liverpool L7 8TX, Merseyside, England

来源：

AGING CELL | 2019年 / 18卷 / 06期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

cell division; geriatric oncology; oncogenesis; transcriptome; tumor; GENE-EXPRESSION PROFILES;

D O I：

10.1111/acel.13041

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is the biggest risk factor for cancer, but the mechanisms linking these two processes remain unclear. Using GTEx and TCGA data, we compared genes differentially expressed with age and genes differentially expressed in cancer among nine human tissues. In most tissues, aging and cancer gene expression pattern changed in the opposite direction. The exception was thyroid and uterus, where we found transcriptomic changes in the same direction in aging and in their corresponding cancers. The overlapping sets between genes differentially expressed with age and genes differentially expressed in cancer across tissues were enriched for several processes, mainly cell cycle and the immune system. Moreover, cellular senescence signatures, derived from a meta-analysis, changed in the same direction as aging in human tissues and in the opposite direction of cancer signatures. Therefore, transcriptomic changes in aging and in cellular senescence might relate to a decrease in cell proliferation, while cancer transcriptomic changes shift toward enhanced cell division. Our results highlight the complex relationship between aging and cancer and suggest that, while in general aging processes might be opposite to cancer, the transcriptomic links between human aging and cancer are tissue-specific.

引用

页数：5

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