Hypofractionated radiotherapy in rectal cancer for elderly patients

被引：2
作者：
Vernat, S. Servagi [1 ]
Guilbert, P. [1 ]
Bouche, G. [1 ]
Ramiandrisoa, F. [1 ]
Bellefqih, S. [1 ]
机构：
[1] Inst Cancerol Jean Godinot, Dept Oncol Radiotherapie, 1 Rue Gen Koenig, F-51726 Reims, France
来源：
CANCER RADIOTHERAPIE | 2018年 / 22卷 / 6-7期
关键词：
Rectal cancer; Elderly patients; Hypofractioned radiotherapy; PREOPERATIVE RADIOTHERAPY; RADIATION-THERAPY; RANDOMIZED-TRIAL; MULTICENTER; CARCINOMA; SURVIVAL; SURGERY; IRRADIATION; TOLERANCE; EFFICACY;
D O I：
10.1016/j.canrad.2018.07.130
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Rectal cancer is a common pathology in the elderly. The standard for advanced rectal tumors is a chemoradiotherapy regimen combined 50 Gy with concomitant chemotherapy followed by a surgery. This treatment induces interruptions of chemoradiotherapy and toxicities G3-4 more important in people over 70 years of age. Hypofractionated radiotherapy 5 x 5 Gy with surgery following week is an alternative. All retrospective studies on this fractionation report an excellent immediate and chronic tolerance. The randomized phase III NACRE trial, comparing these 2 radiotherapy, followed by surgery at 6-8 week, established a standard in the management of the elderly patients. (C) 2018 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：644 / 646
页数：3
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