Effects of prolonged exendin-4 administration on entero-insular axis of normal and streptozotocin-induced diabetic rats

被引:3
作者
Malendowicz, LK
Macchi, C
Nussdorfer, GG
Nowak, KW
Zyterska, A
Ziolkowska, A
机构
[1] Univ Padua, Dept Human Anat & Physiol, Sect Anat, I-35121 Padua, Italy
[2] Karol Marcinkowski Univ Med sci, Dept Histol & Embryol, PL-60781 Poznan, Poland
[3] August Cieszkowski Univ Agr, Dept Anim Physiol & Biochem, PL-60781 Poznan, Poland
关键词
experimental diabetes; exendin-4; glucagon-like peptide 1 receptors; insulin; glucagon; leptin; rat;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The effects of the glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 (EX4) and antagonist EX4(9-39) EX4-A on entero-insular axis have been investigated in normoglycemic and streptozotocin (STZ)-induced diabetic rats. Rats were administered daily subcutaneous injections of 1 nmol/kg EX4 and/or EX4-A for 7 days, and were decapitated 3 h after the last injection. In STZ-untreated rats, EX4 reduced body-weight (BW) gain and raised glycemia, and the effects were prevented by EX4-A; conversely, EX4 did not alter plasma concentrations of-insulin, glucagon and leptin. STZ-treated rats displayed body and hematochemical alterations typical of experimental diabetes: decrease in BW and insulin blood level, coupled with normal glucagon plasma concentration and marked hyperglycemia. In diabetic rats, both EX4 and EX4-A decreased BW gain, thereby suggesting a mechanism at least in part independent of GLP-1 receptors. EX4 did not alter glucagon blood level, but decreased glycemia and raised insulin and leptin plasma levels. These effects were annulled by EX4-A, which indicates that they occur through the activation of GLP-1 receptors. Collectively, our findings add support to the view that EX4 can be considered an important therapeutical too] to improve glucose metabolism in diabetes.
引用
收藏
页码:763 / 766
页数:4
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