Synthesis and Antimicrobial Activity of Azolyl Pyrimidinyl Acetamides

被引：1

作者：

Basha, Hussain N. ^{[1
]}

Rekha, T. ^{[1
]}

Guda, Dinneswara Reddy ^{[2
]}

Padmaja, Adivireddy ^{[1
]}

Padmavathi, V ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati, Andhra Pradesh, India

[2] Sogang Univ, Dept Chem, Seoul, South Korea

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2022年 / 42卷 / 08期

关键词：

Polycyclic heteroaromatic compounds; antimicrobial activity; oxazole; thiazole; imidazole; pyrimidine; EFFICIENT SYNTHESIS; GREEN APPROACH; AMINES; WATER; ACID;

D O I：

10.1080/10406638.2021.1936084

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of azolyl pyrimidinyl acetamides were prepared from azolyl glycinate and 4,6-diaryl/heteroarylpyrimidinyl-2-amines in the presence of DMAP under ultrasonication. Nitrophenyl, pyridinyl and indolyl substituted thiazolyl pyrimidinyl acetamides (9c, 9e, 9f) and imidazolyl pyrimidinyl acetamides (10c, 10e, 10f) showed excellent antibacterial activity against B. subtilis and MBC is 2xMIC. The compounds 9c, 10c and 10e also showed excellent antifungal activity against A. niger and MFC is 2xMIC.

引用

页码：5398 / 5410

页数：13

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