Pulmonary veno-occlusive disease after autologous bone marrow transplant in a child with stage IV neuroblastoma: Case report and literature review

被引：29

作者：

Trobaugh-Lotrario, AD

Greffe, B

Deterding, R

Deutsch, G

Quinones, R

机构：

[1] Childrens Hosp, Sect Pediat Hematol Oncol Bone Marrow Transplanta, Denver, CO 80218 USA

[2] Childrens Hosp, Sect Pediat Pulmonol, Denver, CO 80218 USA

[3] Childrens Hosp, Sect Pediat Pathol, Denver, CO 80218 USA

[4] Univ Colorado, Sch Med, Denver, CO USA

[5] Univ Colorado, Ctr Canc, Denver, CO 80262 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2003年 / 25卷 / 05期

关键词：

malignancy; pulmonary verso-occlusive disease; transplantation;

D O I：

10.1097/00043426-200305000-00011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pulmonary verso-occlusive disease (PVOD) is a rare. almost universally fatal complication of chemotherapy and bone marrow transplantation with few treatment options. A 19-month-old boy with stage 4 neuroblastoma with fatal PVOD following high-dose chemotherapy with autologous peripheral blood stein cell rescue is described here. A comprehensive literature review revealed 40 case reports of PVOD in oncology patients. Various therapeutic modalities were attempted, with four survivors. PVOD should be considered in patients with dyspnea and cardiomegaly. Less invasive diagnostic methods and more effective therapies are needed.

引用

页码：405 / 409

页数：5

共 20 条

[1] FATAL PULMONARY ARTERIAL OCCLUSIVE VASCULAR-DISEASE FOLLOWING CHEMOTHERAPY IN A 9-MONTH-OLD INFANT [J].