HLA-G alleles and HLA-G 14 bp polymorphisms in a Brazilian population

被引：46

作者：

Castelli, E. C. ^{[1
]}

Mendes-Junior, C. T. ^{[1
]}

Donadi, E. A. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Med, Div Clin Immunol, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

TISSUE ANTIGENS | 2007年 / 70卷 / 01期

关键词：

Brazil; HLA-G; polymorphism; South America;

D O I：

10.1111/j.1399-0039.2007.00855.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Brazilians represent one of the most heterogeneous populations in the world as the result of five centuries of interethnic crosses. We investigated the polymorphism of the HLA-G locus in a Brazilian urban sample. HLA-G alleles were determined by SBT analysis of exons 2-4 and 8 in 103 unrelated individuals. The genotyping analysis identified 11 different HLA-G alleles, including the recently described G*010110 allele, and four new variants in this population. These data indicate that this Brazilian population presents high HLA-G allelic polymorphism, suggesting increased levels of intrapopulational genetic diversity that may be because of the admixed nature of the sample. This is the first study regarding HLA-G genotyping that was performed at such refined resolution level in this heterogeneous population.

引用

页码：62 / 68

页数：7

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