Asymmetric bis(oxazoline)-Ni(ii) catalyzed α-hydroxylation of cyclic β-keto esters under visible light

被引：8

作者：

Yin, Hao ^{[1
]}

Wang, Chao-Jie ^{[1
]}

Zhao, Yu-Gen ^{[1
]}

He, Zi-Yang ^{[1
]}

Chu, Ming-Ming ^{[2
]}

Wang, Yi-Feng ^{[1
]}

Xu, Dan-Qian ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Dept Green Chem & Technol, State Key Lab Breeding Base Green Chem Synth Tech, Key Lab Green Pesticides & Cleaner Prod Technol Z, Hangzhou 310014, Peoples R China

[2] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 30期

关键词：

PHASE-TRANSFER CATALYSTS; COMPLEXES; FLUORINATION; RESOLUTION; OXIDATION; LIGANDS;

D O I：

10.1039/d1ob00546d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using visible light as a driving force and molecular oxygen as a green oxidant, we developed bis(oxazoline)-Ni(acac)(2) catalyzed asymmetric alpha-hydroxylation of beta-keto esters under low photosensitizer loading, and the protocol enabled an efficient transformation to provide the desired chiral alpha-hydroxy-beta-keto esters in high yields (up to 99%) and enantioselectivities (up to 99% ee) at room temperature.

引用

收藏

页码：6588 / 6592

页数：6

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