Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

被引：326

作者：

Jowaed, Ahmad ^{[1
]}

Schmitt, Ina ^{[1
]}

Kaut, Oliver ^{[1
]}

Wuellner, Ullrich ^{[1
]}

机构：

[1] Univ Bonn, Dept Neurol, Univ Klinikum Bonn, D-53105 Bonn, Germany

来源：

JOURNAL OF NEUROSCIENCE | 2010年 / 30卷 / 18期

关键词：

DNA METHYLATION; MESSENGER-RNA; GENE; PROMOTER; CORTEX;

D O I：

10.1523/JNEUROSCI.6119-09.2010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. We found that methylation of human SNCA intron 1 decreased gene expression, while inhibition of DNA methylation activated SNCA expression. Methylation of SNCA intron 1 was reduced in DNA from sporadic PD patients' substantia nigra, putamen, and cortex, pointing toward a yet unappreciated epigenetic regulation of SNCA expression in PD.

引用

页码：6355 / 6359

页数：5

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