A concise enantioselective total synthesis of (+)-epi-muricatacin, using asymmetric hydrogenation/intramolecular iodoetherification as key steps

被引：27

作者：

Kumaraswamy, Gullapalli ^{[1
]}

Ramakrishna, Duggirala ^{[1
]}

Santhakumar, Kondapalli ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 3, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, NMR Div, Hyderabad 500607, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 05期

关键词：

D-ISOASCORBIC ACIDS; GAMMA-LACTONES; ENANTIOPURE HYDROXYLACTONES; STEREOSELECTIVE-SYNTHESIS; TRANSFER HYDROGENATION; (-)-MURICATACIN; MURICATACIN; (+)-MURICATACIN; DIHYDROXYLATION; REARRANGEMENT;

D O I：

10.1016/j.tetasy.2010.02.024

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A concise enantioselective total synthesis of (+)-epi-muricatacin, a potent cytotoxic agent, is described. A key feature of this protocol is a catalytic asymmetric hydrogenation and a chiral auxiliary mediated intramolecular iodoetherification to ensure a high degree of distereo- and enantiocontrol. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：544 / 548

页数：5

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