The key role of the level of ACE2 gene expression in SARS-CoV-2 infection

被引：0

作者：

Lecarpentier, Yves ^{[1
]}

Vallee, Alexandre ^{[2
]}

机构：

[1] Grand Hop Est Francilien GHEF, Ctr Rech Clin, Meaux, Seine & Marne, France

[2] Foch Hosp, Dept Clin Res & Innovat, Suresnes, France

来源：

AGING-US | 2021年 / 13卷 / 11期

关键词：

ACE2; Alzheimer's disease; aging; COVID-19; SARS-COV-2; ANGIOTENSIN-CONVERTING ENZYME; ALZHEIMERS-DISEASE; AMYLOID-BETA; MOUSE MODEL; RECEPTOR; SYSTEM; BRAIN; AXIS;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SARS-CoV-2 more readily affects the elderly, especially as they present co-morbidities. In the COVID-19 pathogeny, ACE2 appears to be the key cell receptor for SARS-CoV-2 to infect humans. The level of ACE2 gene expression influences the susceptibility of contracting SARS-CoV-2. In circumstances in which the ACE2 level is low, the incidence of COVID-19 seems to be fewer. Two clinical patterns illustrate this observation, i. e., in infants and in Alzheimer's disease (AD). Very young children and AD patients get little COVID-19, in part probably due to decreased expression of ACE2. The determination of the nasal level of ACE2 gene expression could provide a useful scale to predict the susceptibility to contract the SARS-CoV-2 infection.

引用

页码：14552 / 14556

页数：5

共 39 条

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