Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses

被引：31

作者：

Matsuda, Shingo ^{[2
]}

Saika, Shizuko ^{[1
]}

Amano, Keiko ^{[1
]}

Shimizua, Eiji ^{[2
]}

Sajiki, Junko ^{[1
]}

机构：

[1] Chiba Prefectural Inst Publ Hlth, Chuou Ku, Chiba 2607815, Japan

[2] Chiba Univ, Grad Sch Med, Dept Integrat Neurophysiol, Chuou Ku, Chiba 2608670, Japan

来源：

CHEMOSPHERE | 2010年 / 78卷 / 07期

关键词：

Serotonin; Dopamine; Hippocampus; Striatum; BPA disappearance; PERFORMANCE LIQUID-CHROMATOGRAPHY; ELECTROCHEMICAL DETECTION; SEXUAL-DIFFERENTIATION; PERINATAL EXPOSURE; NONHUMAN-PRIMATES; AUTISM; DOPAMINE; MICE; ESTROGEN; BLOOD;

D O I：

10.1016/j.chemosphere.2009.11.010

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

To examine whether exposure to bisphenol A (BPA) at low levels affect brain function, monoamine concentrations in hippocampus, striatum and brain stem, were investigated in neonatal male rats injected intracranially with BPA at 0-10 mu g kg(-1). Significant increases of serotonin (5-HT) in hippocampus, 5-HIAA and 5-HIAA/5-HT in brain stem, dopamine (DA) and DOPAC in striatum were observed at 28 d after the injection on postnatal day 2. At 7 d after the injection, increases in 5-HT and norepinephrine (NE) and decreases in DOPAC and 5-HIAA were observed in hippocampus. To investigate the degradation of BPA in brain, we also measured BPA concentrations of whole neonatal rat brain. Free BPA disappeared from brain tissues within 5 h, even when the highest dose (1000 mu g kg(-1)) was injected. The present results suggest that BPA exposure at lower doses than environmentally relevant levels may have a great impact on monoamine levels in neonatal brain over 28 d after its disappearance. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：894 / 906

页数：13

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