Formulation and Evaluation of Hybrid Niosomal In Situ Gel for Intravesical Co-Delivery of Curcumin and Gentamicin Sulfate

被引:22
作者
Gugleva, Viliana [1 ]
Michailova, Victoria [2 ]
Mihaylova, Rositsa [3 ]
Momekov, Georgi [3 ]
Zaharieva, Maya Margaritova [4 ]
Najdenski, Hristo [4 ]
Petrov, Petar [5 ]
Rangelov, Stanislav [5 ]
Forys, Aleksander [6 ]
Trzebicka, Barbara [6 ]
Momekova, Denitsa [2 ]
机构
[1] Med Univ Varna, Fac Pharm, Dept Pharmaceut Technol, 84 Tsar Osvoboditel Str, Varna 9000, Bulgaria
[2] Med Univ Sofia, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, 2 Dunav Str, Sofia 1000, Bulgaria
[3] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, 2 Dunav Str, Sofia 1000, Bulgaria
[4] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Dept Infect Microbiol, 26 Acad G Bonchev Str, Sofia 1113, Bulgaria
[5] Bulgarian Acad Sci, Inst Polymers, Bl 103 Akad G Bonchev Str, Sofia 1113, Bulgaria
[6] Polish Acad Sci, Ctr Polymer & Carbon Mat, Ul M Curie Sklodowskiej 34, PL-41819 Zabrze, Poland
关键词
curcumin; gentamicin sulfate; drug delivery; in situ gels; simultaneously loaded niosomes; stimuli-responsiveness; poloxamer; vesicular systems; HYDROGELS; RELEASE;
D O I
10.3390/pharmaceutics14040747
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The current study describes the elaboration of a hybrid drug delivery platform for an intravesical application based on curcumin/gentamicin sulfate simultaneously loaded niosomes incorporated into thermosensitive in situ gels. Series of niosomes were elaborated via the thin film hydration method, evaluating the impact of non-ionic surfactants', cholesterol's, and curcumin's concentration. The formulation composed of equimolar ratio of Span 60, Tween 60, and 30 mol% cholesterol was selected as the optimal composition, due to the high entrapment efficiency values obtained for both drugs, and appropriate physicochemical parameters (morphology, size, PDI, and zeta potential), therefore, was further incorporated into Poloxamers (407/188) and Poloxamers and chitosan based in situ gels. The developed hybrid systems were characterized with sol to gel transition in the physiological range, suitable rheological and gelling characteristics. In addition, the formed gel structure at physiological temperatures determines the retarded dissolution of both drugs (vs. niosomal suspension) and sustained release profile. The conducted microbial studies of selected niosomal in situ gels revealed the occurrence of a synergetic effect of the two compounds when simultaneously loaded. The findings indicate that the elaborated thermosensitive niosomal in situ gels can be considered as a feasible platform for intravesical drug delivery.
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页数:23
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