How Different Parts of the World Provide New Insights Into Food Allergy

被引：42

作者：

Tham, Elizabeth Huiwen ^{[1
,2
,3
]}

Leung, Donald Y. M. ^{[3
,4
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore

[2] Khoo Teck Puat Natl Univ, Natl Univ Hlth Syst, Childrens Med Inst, Natl Univ Hosp, Singapore, Singapore

[3] Natl Jewish Hlth, Dept Pediat, Denver, CO USA

[4] Univ Colorado Denver, Hlth Sci Ctr, Dept Pediat, Aurora, CO USA

来源：

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | 2018年 / 10卷 / 04期

关键词：

Food allergy; genetics; atopic dermatitis; food allergy prevention; PEANUT ALLERGY; EGG ALLERGY; CHALLENGE-PROVEN; IGE CONCENTRATIONS; HAZELNUT ALLERGY; NATURAL-HISTORY; FILAGGRIN GENE; UNITED-STATES; RISK-FACTORS; PREVALENCE;

D O I：

10.4168/aair.2018.10.4.290

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The prevalence and patterns of food allergy are highly variable in different parts of the world. Differences in food allergy epidemiology may be attributed to a complex interplay of genetic, epigenetic, and environmental factors, suggesting that mechanisms of food allergy may differ in various global populations. Genetic polymorphisms, migration, climate, and infant feeding practices all modulate food allergy risk, and possibly also the efficacy of interventions aimed at primary prevention of food allergy development. Approaches to diagnosis, treatment, and prevention of food allergy should thus be tailored carefully to each population's unique genetic and environmental make-up. Future research in the context of food allergy prevention should focus on elucidating factors determining differential responses between populations.

引用

页码：290 / 299

页数：10

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