Myofibroblast accumulation in healing rat myocardium due to long-term low-dosage nitric oxide synthesis inhibition

被引：9
作者：
Pessanha, MG
Mandarim-De-Lacerda, CA
机构：
[1] State Univ Rio de Janeiro, Inst Biol, Ctr Biomed, Lab Morphometry & Cardiovasc Morphol, Rio De Janeiro, Brazil
[2] Univ Fed Fluminense, Hosp Antonio Pedro, Dept Expt Pathol, Rio De Janeiro, Brazil
来源：
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2000年 / 52卷 / 03期
关键词：
myofibroblast; nitric oxide; myocardial remodeling; alpha-smooth-muscle-actin; fibronectin; collagen; hypertension;
D O I：
10.1016/S0940-2993(00)80027-5
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Inhibition of nitric oxide synthesis causes hypertension, myocardial damage and repair in rats. The myocardial healing process includes changes in extracellular matrix composition associated with the phenotypic modulation of fibroblasts. Early and later lesion areas showed a population of spindle-shaped cells expressing ex-smooth muscle actin content. These cells apparently are associated with type III collagen and fibronectin accumulation in the ischemic lesion areas contributing to maintaining of the mechanical performance of the heart through out the healing process.
引用
收藏
页码：192 / 194
页数：3
相关论文
共 10 条
  • [1] Fibronectin and basement membrane in cardiovascular organogenesis and disease pathogenesis
    Farhadian, F
    Contard, F
    Sabri, A
    Samuel, JL
    Rappaport, L
    [J]. CARDIOVASCULAR RESEARCH, 1996, 32 (03) : 433 - 442
  • [2] GABBIANI G, 1971, EXPERIENTIA, V27, P548
  • [3] LESLIE KO, 1991, AM J PATHOL, V139, P207
  • [4] Stereology and immunohistochemistry of the myocardium in experimental hypertension: Long-term and low-dosage administration of inhibitor of the nitric oxide synthesis
    Pessanha, MG
    Mandarim-de-Lacerda, CA
    Hahn, MD
    [J]. PATHOBIOLOGY, 1999, 67 (01) : 26 - 33
  • [5] ACCUMULATION OF FETAL FIBRONECTIN MESSENGER-RNAS DURING THE DEVELOPMENT OF RAT CARDIAC-HYPERTROPHY INDUCED BY PRESSURE OVERLOAD
    SAMUEL, JL
    BARRIEUX, A
    DUFOUR, S
    DUBUS, I
    CONTARD, F
    KOTELIANSKY, V
    FARHADIAN, F
    MAROTTE, F
    THIERY, JP
    RAPPAPORT, L
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (05) : 1737 - 1746
  • [6] SPERANZA ML, 1987, COLLAGEN REL RES, V7, P115
  • [7] Metabolic responses of extracellular matrix in tissue repair
    Weber, KT
    [J]. ANNALS OF MEDICINE, 1997, 29 (04) : 333 - 338
  • [8] WEIHRAUCH D, 1994, CELL MOL BIOL RES, V40, P105
  • [9] Willems IEMG, 1996, J PATHOL, V179, P321
  • [10] Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts
    Zhou, GP
    Kandala, JC
    Tyagi, SC
    Katwa, LC
    Weber, KT
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1996, 154 (02) : 171 - 178
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